Document Detail


Genetic susceptibility to asthma and atopy among Chinese in Singapore--linkage to markers on chromosome 5q31-33.
MedLine Citation:
PMID:  11488668     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Asthma and atopy are complex genetic traits, influenced by the interaction of multiple genes and environmental factors. Linkage of these traits to chromosome 5q31-33 has been shown in other populations, but has not been well studied in the Chinese. We studied linkage between asthma and atopy with markers on chromosome 5q31-33 in the Singapore Chinese. This region contains many candidate genes, including the cytokine gene cluster. METHODS: We recruited 88 Chinese families with at least two affected offspring, totaling 373 subjects, with 125 and 119 sib-pairs for atopy and asthma, respectively. All individuals were genotyped with 19 polymorphic microsatellite markers spanning a distance of 41 cM along chromosome 5q31-33. Affected sib-pair and multipoint linkage analysis was performed. RESULTS: There was evidence for linkage of the asthma and atopy phenotypes with three markers, D5S2110, D5S2011, and D5S412 (P values of 0.001 to 0.00001). Multipoint analysis further substantiated this (nonparametric linkage scores of 1.8-2.9). These findings suggest that susceptibility genes for asthma and atopy are found in this region in the Chinese. CONCLUSION: This study has shown linkage of atopy and asthma to chromosome 5q31-33 in a heterogeneous Chinese population. These findings further substantiate the notion that chromosome 5q31-33 contains "universally" important susceptibility genes for these traits.
Authors:
L P Shek; A H Tay; F T Chew; D L Goh; B W Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Allergy     Volume:  56     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-07     Completed Date:  2001-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  749-53     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, National University of Singapore, Lower Kent Ridge Road, Singapore 119074.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Asian Continental Ancestry Group / genetics*
Asthma / genetics*
Child
Child, Preschool
Chromosomes, Human, Pair 5 / genetics*
Female
Genetic Predisposition to Disease*
Heterozygote
Humans
Hypersensitivity / genetics*
Infant
Linkage (Genetics)*
Male
Microsatellite Repeats / genetics
Middle Aged
Singapore / ethnology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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