Document Detail


Genetic studies in Parkinson's disease with an alpha-synuclein/NACP gene polymorphism in Japan.
MedLine Citation:
PMID:  11207390     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dinucleotide repeat polymorphism has been observed in the promoter of the alpha-synuclein (alpha-SYN)/NAC precursor protein (NACP) gene. Alpha-SYN/NACP allele 3 (described by Xia et al. (Ann. Neurol., 40 (1996) 207), equivalent to allele 1 described by Krüger et al. (Ann. Neurol. 45 (1999) 611) is reported to be significantly more frequent among patients with sporadic Parkinson's disease (sPD) than controls. In this study, we genotyped the same alpha-SYN/NACP polymorphism in Japanese sPD patients and healthy controls, but found that any aliele showed no significant difference between the two groups.
Authors:
Y Izumi; H Morino; M Oda; H Maruyama; F Udaka; M Kameyama; S Nakamura; H Kawakami
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  300     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-06-26     Completed Date:  2001-08-09     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  125-7     Citation Subset:  IM    
Affiliation:
Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alleles
DNA Mutational Analysis
Dinucleotide Repeats / genetics*
Female
Genetic Predisposition to Disease / ethnology,  genetics
Genetic Testing*
Genotype
Humans
Japan
Male
Middle Aged
Mutation / physiology*
Nerve Tissue Proteins / genetics*
Parkinson Disease / genetics*,  metabolism,  physiopathology
Polymorphism, Genetic / genetics*
Promoter Regions, Genetic / genetics
Risk Factors
Synucleins
alpha-Synuclein
Chemical
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/SNCA protein, human; 0/Synucleins; 0/alpha-Synuclein

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