| Genetic single-nucleotide polymorphisms of inflammation-related factors associated with risk of lung cancer. | |
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MedLine Citation:
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PMID: 23292870 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This study was to investigate the association of inflammation-related factors with the risk of lung cancer. All subjects were unrelated ethnic Han Chinese in Liaoning province. Our study conducted a hospital-based case-control study, the case group consisted of 193 histologically diagnosed lung cancer patients, and 211 controls were selected from cancer-free patients at the same. 5 single-nucleotide polymorphisms (TGFβ1 +869T/C, IL6 -634C/G, TGFβ1 -509C/T, IL1β -511C/T, and IL1α -899C/T) in inflammatory genes (IL1, IL6, TGF) were analyzed by Taqman real-time PCR method. All statistical analyses were performed with statistical product and service solutions v13.0. The genotype distribution frequency of IL6 -634C/G exists significant difference between case and control group. Individuals carrying -634GG and CG genotype had a higher risk of lung cancer. The risk allele was G in IL6 -634C/G. |
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Authors:
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Lu Bai; Hong Yu; Hetong Wang; Hongxin Su; Junhua Zhao; Yuxia Zhao |
Publication Detail:
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Type: Journal Article Date: 2013-01-06 |
Journal Detail:
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Title: Medical oncology (Northwood, London, England) Volume: 30 ISSN: 1559-131X ISO Abbreviation: Med. Oncol. Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-01-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9435512 Medline TA: Med Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 414 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, 110001, Shenyang, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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