Document Detail


Genetic single-nucleotide polymorphisms of inflammation-related factors associated with risk of lung cancer.
MedLine Citation:
PMID:  23292870     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This study was to investigate the association of inflammation-related factors with the risk of lung cancer. All subjects were unrelated ethnic Han Chinese in Liaoning province. Our study conducted a hospital-based case-control study, the case group consisted of 193 histologically diagnosed lung cancer patients, and 211 controls were selected from cancer-free patients at the same. 5 single-nucleotide polymorphisms (TGFβ1 +869T/C, IL6 -634C/G, TGFβ1 -509C/T, IL1β -511C/T, and IL1α -899C/T) in inflammatory genes (IL1, IL6, TGF) were analyzed by Taqman real-time PCR method. All statistical analyses were performed with statistical product and service solutions v13.0. The genotype distribution frequency of IL6 -634C/G exists significant difference between case and control group. Individuals carrying -634GG and CG genotype had a higher risk of lung cancer. The risk allele was G in IL6 -634C/G.
Authors:
Lu Bai; Hong Yu; Hetong Wang; Hongxin Su; Junhua Zhao; Yuxia Zhao
Publication Detail:
Type:  Journal Article     Date:  2013-01-06
Journal Detail:
Title:  Medical oncology (Northwood, London, England)     Volume:  30     ISSN:  1559-131X     ISO Abbreviation:  Med. Oncol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-01-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9435512     Medline TA:  Med Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  414     Citation Subset:  IM    
Affiliation:
Department of Radiation Oncology, First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, 110001, Shenyang, China.
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