Document Detail


Genetic and shared environmental influences on adolescent BMI: interactions with race and sex.
MedLine Citation:
PMID:  9803019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study uses a behavioral genetic design to investigate the genetic and environmental influences on variation in adolescent body mass index (BMI) and to determine whether the relative influences of genetic and environmental factors on variation in BMI are similar across racial groups and sexes. Data for the present study come from the National Longitudinal Study on Adolescent Health (Add Health), a large, nationally representative study of adolescent health and health-related behaviors. The Add Health sample contains a subset of sibling pairs that differs in levels of genetic relatedness, making it well suited for behavioral genetics analyses. The present study examines whether genetic and environmental influences on adolescent BMI are the same for males and females and for Black and White adolescents. Results indicate that genetic factors contribute substantially to individual differences in adolescent BMI, explaining between 45 and 85% of the variance in BMI. Furthermore, based on an analysis of opposite-sex sibling pairs, the genes that influence variation in adolescent BMI are similar for males and females. However, the relative importance of genetic and environmental influences on variation in BMI differs for males and females and for Blacks and Whites. Although parameter estimates could be constrained to be equal for Black and White males, they could not be constrained to be equal for Black and White females. Moreover, the best-fitting model for Black females was an ADE model, for White females it was an ACE model, and for males it was an AE model. Thus, shared environmental influences are significant for White female adolescents, but not for Black females or males. Likewise, nonadditive genetic influences are indicated for Black females, but not for White females or males. Implications of these results are discussed.
Authors:
K C Jacobson; D C Rowe
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Behavior genetics     Volume:  28     ISSN:  0001-8244     ISO Abbreviation:  Behav. Genet.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1999-02-16     Completed Date:  1999-02-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0251711     Medline TA:  Behav Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  265-78     Citation Subset:  IM    
Affiliation:
Department of Human Development and Family Studies, Pennsylvania State University, University Park 16802, USA. kjacobso@u.arizona.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent / physiology*
African Continental Ancestry Group
Body Constitution / ethnology,  genetics*
Body Mass Index*
Chi-Square Distribution
Cross-Sectional Studies
Environment*
European Continental Ancestry Group
Female
Humans
Male
Matched-Pair Analysis
Models, Genetic*
Nuclear Family*
Sampling Studies
Sex Factors
United States / epidemiology
Grant Support
ID/Acronym/Agency:
P01-HD31921/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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