Document Detail

Genetic screening of endocrine tumour syndromes with DNA probes: the example of medullary thyroid carcinoma.
MedLine Citation:
PMID:  2575577     Owner:  NLM     Status:  MEDLINE    
Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal-dominant syndrome characterized by medullary thyroid carcinoma (MTC), pheochromocytoma and parathyroid hyperplasia. Recent reports have assigned the locus of MEN2A to the pericentromeric region of chromosome 10. Through the 'Groupe d'Etude des Tumeurs à Calcitonine', we have evaluated the ability to predict the carrier state using DNA probes. Our results suggest that the restriction fragment length polymorphism method can be used to identify individuals at risk within MEN2A families. They may then be followed by conventional endocrine methods for the onset of neoplastic changes, limiting the risk of subsequent metastatic disease. The method also permits the exclusion of further screening for family members at very low risk. Extension of the screening program can now be anticipated for other inherited forms of MTC, such as familial MTC without pheochromocytoma or other endocrinological tumor syndromes such as MEN1 for which the locus has also recently been mapped.
H Sobol; S A Narod; D Assouline; G M Lenoir
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Hormone research     Volume:  32     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  1989  
Date Detail:
Created Date:  1990-03-13     Completed Date:  1990-03-13     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  34-40     Citation Subset:  IM    
International Agency for Research on Cancer, Lyon, France.
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MeSH Terms
Carcinoma / genetics*
DNA Probes*
Genetic Testing*
Multiple Endocrine Neoplasia / genetics*
Thyroid Neoplasms / genetics*
Reg. No./Substance:
0/DNA Probes

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