| Genetic risk of Alzheimer's disease: advising relatives. | |
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MedLine Citation:
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PMID: 11136203 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Clinicians are increasingly asked by relatives of patients with Alzheimer's disease to advise on their genetic risk of developing Alzheimer's disease in later life. Many clinicians find this a difficult question to answer. AIMS: To provide information for old age psychiatrists wishing to advise relatives of their risk of developing Alzheimer's disease. METHOD: A selective review of the key literature on the genetic epidemiology of Alzheimer's disease. RESULTS: Currently a DNA diagnosis is attainable in some 70% of families with autosomal dominant Alzheimer's disease. In first-degree relatives of most cases, risk is increased some three- or four-fold relative to controls, but only one-third of this is realised in the average life span. Apolipoprotein E genotyping cannot be used as a predictive test and confers only minimal diagnostic benefit. CONCLUSIONS: Pedigrees with familial Alzheimer's disease should be referred to a Regional Centre for Medical Genetics. Accurate risk prediction is not possible in the vast majority of pedigrees with Alzheimer's disease, although it is possible for the psychiatrist to give a rough estimate of the risk, which can reasonably the couched in reassuring terms. |
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Authors:
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M B Liddell; S Lovestone; M J Owen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: The British journal of psychiatry : the journal of mental science Volume: 178 ISSN: 0007-1250 ISO Abbreviation: Br J Psychiatry Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-01-26 Completed Date: 2001-02-15 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0342367 Medline TA: Br J Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 7-11 Citation Subset: IM |
Affiliation:
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Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK. liddellmb@cardiff.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / diagnosis, genetics* Apolipoproteins E / genetics Genetic Counseling Genetic Testing* Genotype Humans Pedigree Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E |
| Comments/Corrections | |
Comment In:
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Br J Psychiatry. 2001 Jul;179:73-4
[PMID:
11435273
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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