Document Detail


Genetic resistance factor for HIV-1 and immune response to varicella zoster virus.
MedLine Citation:
PMID:  11211001     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 32 bp deletion in the chemokine receptor CCR5 gene modulates HIV-1 infection. However, whether this CCR5 gene variation modifies immunity to common herpesvirus infections is unknown. We investigated whole blood IgG concentrations of 157 normal adult blood donors. Also we assessed whether the 32 bp deletion of CCR5 (delta32CCR5) was associated with circulating IgG to four herpesviruses: varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and herpes simplex virus type 1 and type 2. Individuals who carried delta32CCR5 were 9.2 times more likely to be seronegative for varicella zoster virus than non-carriers (95% CI 2.9-29.1), but no differences were seen for the other herpesviruses studied. Variation in CCR5 may modulate humoral immunity to varicella zoster virus.
Authors:
J K Wiencke; K T Kelsey; Z F Zuo; A Weinberg; M R Wrensch
Publication Detail:
Type:  Letter; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lancet     Volume:  357     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-08     Completed Date:  2001-02-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  England    
Other Details:
Languages:  eng     Pagination:  360-1     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Chickenpox / genetics*,  immunology*
Female
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Polymorphism, Genetic*
Receptors, CCR5 / immunology*
Grant Support
ID/Acronym/Agency:
ES0002/ES/NIEHS NIH HHS; ES06717/ES/NIEHS NIH HHS; P42ES04705/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, CCR5

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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