| Genetic rescue of an endangered mammal by cross-species nuclear transfer using post-mortem somatic cells. | |
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MedLine Citation:
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PMID: 11581663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since the advent of procedures for cloning animals, conservation biologists have proposed using this technology to preserve endangered mammals. Here we report the successful cloning of a wild endangered animal, Ovis orientalis musimon, using oocytes collected from a closely related, domesticated species, Ovis aries. We injected enucleated sheep oocytes with granulosa cells collected from two female mouflons found dead in the pasture. Blastocyst-stage cloned embryos transferred into sheep foster mothers established two pregnancies, one of which produced an apparently normal mouflon. Our findings support the use of cloning for the expansion of critically endangered populations. |
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Authors:
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P Loi; G Ptak; B Barboni; J Fulka; P Cappai; M Clinton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nature biotechnology Volume: 19 ISSN: 1087-0156 ISO Abbreviation: Nat. Biotechnol. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-02 Completed Date: 2001-11-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9604648 Medline TA: Nat Biotechnol Country: United States |
Other Details:
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Languages: eng Pagination: 962-4 Citation Subset: IM |
Affiliation:
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Department of Structure, Functions, Animal Pathology and Biotechnology, University of Teramo, Italy. loi@ifv.vet.unite.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Wild Blastocyst Cells, Cultured Cloning, Organism / veterinary* Conservation of Natural Resources* Embryo Transfer / veterinary Female Genotype Microsatellite Repeats Nuclear Transfer Techniques* Oocytes / cytology Ruminants* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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