Document Detail

Genetic regulation of amniotic fluid TNF-alpha and soluble TNF receptor concentrations affected by race and preterm birth.
MedLine Citation:
PMID:  18807256     Owner:  NLM     Status:  MEDLINE    
Racial disparity in spontaneous preterm birth (PTB) between African Americans and Caucasians in the US is unexplained, but is probably related to differences in amniotic fluid (AF) inflammatory cytokine profiles. Therefore, this study analyzed the association of 34 single nucleotide polymorphisms (SNPs) in TNF-alpha and its receptor genes (TNFR1 and TNFR2) with AF TNF-alpha and soluble TNF receptor (R1 and R2) concentrations in PTB. Samples consisted of African American and Caucasian cases (PTB), and controls (term birth) for which both cytokine, and maternal and fetal genotype data were available. Analyses were performed with genotype, case, and maker-status interaction in the model for log transformed cytokine concentrations. In Caucasians, two interactions between genotype and pregnancy outcome associated with cytokine concentrations, whereas 14 gene variants in African Americans showed interactions with pregnancy outcome, and 13 showed association with genetic markers. In conclusion, cytokine concentrations in African American preterm births can be partially explained by interactions between pregnancy outcome, SNPs and infection. This does not appear to be the case in Caucasians. These findings may be important in understanding disparity in rates of PTB between the two populations.
Ramkumar Menon; Digna R Velez; Nicole Morgan; Salvatore J Lombardi; Stephen J Fortunato; Scott M Williams
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-21
Journal Detail:
Title:  Human genetics     Volume:  124     ISSN:  1432-1203     ISO Abbreviation:  Hum. Genet.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-09     Completed Date:  2008-10-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  243-53     Citation Subset:  IM    
The Perinatal Research Center, 2300 Patterson Street, Nashville, TN 37203, USA.
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MeSH Terms
African Continental Ancestry Group
Amniotic Fluid / metabolism*
Case-Control Studies
European Continental Ancestry Group
Polymorphism, Single Nucleotide*
Pregnancy Outcome
Premature Birth / genetics*
Receptors, Tumor Necrosis Factor / biosynthesis*,  genetics*
Receptors, Tumor Necrosis Factor, Type I / metabolism
Receptors, Tumor Necrosis Factor, Type II / metabolism
Tumor Necrosis Factor-alpha / biosynthesis*,  genetics*
Reg. No./Substance:
0/Receptors, Tumor Necrosis Factor; 0/Receptors, Tumor Necrosis Factor, Type I; 0/Receptors, Tumor Necrosis Factor, Type II; 0/Tumor Necrosis Factor-alpha

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