Document Detail

Genetic polymorphisms of killer cell immunoglobulin-like receptors are associated with susceptibility to psoriasis vulgaris.
MedLine Citation:
PMID:  15140215     Owner:  NLM     Status:  MEDLINE    
To elucidate the association between killer cell immunoglobulin-like receptors (KIRs) and psoriasis vulgaris (PV), we typed 14 KIR genes in 96 Japanese cases and 50 healthy controls using PCR with sequence-specific primers (PCR-SSP). Here we report an interesting association between certain KIRs and Japanese cases with PV. The frequencies of KIR2DS1 and KIR2DL5 were significantly increased in PV cases compared with controls (KIR2DS1, 43 of 96 (45%) in cases vs 14 of 50 (28%) in controls; KIR2DL5, 46 of 96 (48%) in cases vs 15 of 50 (30%) in controls, p<0.05 for both), and the frequency of carriage of at least one presumed "B" haplotype, inferred from patterns including KIR2DL2, KIR2DL5, and/or various combinations of activating KIRs, was also statistically increased in the PV cases (53 of 96 (55%) in cases vs 18 of 50 (36%) in controls, p<0.04). The increase in KIR2DS1 has also been observed in psoriatic arthritis, another HLA-Cw6-associated disease (Martin et al, 2002). Accordingly, KIR2DS1 may be a common denominator of both diseases.
Yu Suzuki; Yoshiaki Hamamoto; Yumie Ogasawara; Kimi Ishikawa; Yoshiaki Yoshikawa; Takehiko Sasazuki; Masahiko Muto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  122     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-13     Completed Date:  2004-06-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1133-6     Citation Subset:  IM    
Department of Dermatology and Biomolecular Recognition, School of Medicine, Yamaguchi University, Yamaguchi, Japan.
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MeSH Terms
Genetic Predisposition to Disease
Killer Cells, Natural / physiology*
Polymorphism, Genetic*
Psoriasis / genetics*,  immunology*
Receptors, Immunologic / genetics*
Receptors, KIR
Receptors, KIR2DL1
Receptors, KIR2DL2
Reg. No./Substance:
0/KIR2DL2 protein, human; 0/Receptors, Immunologic; 0/Receptors, KIR; 0/Receptors, KIR2DL1; 0/Receptors, KIR2DL2

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