| Genetic polymorphisms of the interleukin-1 gene and early marginal bone loss around endosseous dental implants. | |
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MedLine Citation:
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PMID: 12869004 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dental implant surgery commonly proceeds in two stages. It is generally accepted that bone loss around implants does not occur at stage-II surgery because implants do not receive mechanical loading. However, early marginal bone loss around implants occasionally does occur during the healing period. Genetic polymorphisms in the interleukin-1 (IL-1) gene have been reported to be important for bone homeostasis and susceptibility to bone disease. We therefore investigated whether the idiopathic early marginal bone loss around implants is related to polymorphisms in the IL-1 gene. We performed a case-control study. Patients demonstrating marginal bone loss around implants at stage-II surgery were designated as the 'marginal bone loss (+)' group and those without bone loss as the 'marginal bone loss (-)' group. Polymorphisms of the IL-1alpha and IL-1beta genes (IL-1A-889, IL-1B-511 and IL-1B+3954) were detected by restriction fragment length polymorphism using NcoI, AvaI and TaqI after polymerase chain reactions. A total of 251 implants were placed in 39 patients. Marginal bone loss was observed in 36 implants. The patients with IL-1B-511 2/2 genotype exhibited a significantly higher occurrence of marginal bone loss than those with IL-1B-511 1/1 or 1/2 genotypes (OR=5.63; 95% CI=1.20-26.42; P=0.033). Multiple logistic regression analyses showed a markedly increased odds ratio (OR=10.86; 95% CI=1.64-71.90) in IL-1B-511 2/2 genotype carriers, while ORs of the other risk factors for bone loss, such as age, smoking status, post-menopausal women and bone quality, remained between 0.44 and 6.20. There was no significant difference in the distributions of the IL-1B+3954 and IL-1 A-889 genotypes between cases and controls. These data suggest that the IL-1B-511 2/2 genotype has a significant association with the incidence of early marginal bone loss around endosseous implants. |
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Authors:
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Hitomi Shimpuku; Yasuhiro Nosaka; Tatsuya Kawamura; Yoichi Tachi; Mitsuko Shinohara; Kiyoshi Ohura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical oral implants research Volume: 14 ISSN: 0905-7161 ISO Abbreviation: Clin Oral Implants Res Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-07-18 Completed Date: 2003-09-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9105713 Medline TA: Clin Oral Implants Res Country: Denmark |
Other Details:
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Languages: eng Pagination: 423-9 Citation Subset: D |
Affiliation:
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Department of Pharmacology, Osaka Dental University, Hirakata, Osaka, Japan. nskshimpuku@aol.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Alveolar Bone Loss / genetics, immunology* Bone Density / physiology Case-Control Studies Confidence Intervals Dental Implants* Female Genetic Predisposition to Disease Genotype Homeostasis / genetics Humans Interleukin-1 / genetics* Logistic Models Male Middle Aged Odds Ratio Polymorphism, Genetic / genetics* Postmenopause Risk Factors Smoking / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Dental Implants; 0/Interleukin-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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