Document Detail


Genetic polymorphisms in three Iranian populations with different risks of esophageal cancer, an ecologic comparison.
MedLine Citation:
PMID:  15327835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The age-standardized incidence of esophageal cancer (EC) varies from 3 to >100/100,000 per year in different provinces of Iran. This striking variation of incidence is associated with differences in ethnic backgrounds, raising the possibility that genetic factors are involved in the pathogenesis of EC. We compared the frequencies of polymorphisms in ten genes that have been hypothesized to have a role in risk of EC (CYP1A1, CYP2A6, CYP2E1, GSTM1, GSTP1, GSTT1, ADH2, ADH3, ALDH2, and O6-MGMT) among three Iranian ethnic groups with highly varying rates of EC. These three groups included high-risk Turkomans, medium-risk Turks, and low-risk Zoroastrian Persians. Compared to Zoroastrians, Turkomans had higher frequency of four alleles that are speculated to favor carcinogenesis (CYP1A1 m1, CYP1A1 m2, CYP2A6*9, and ADH2*1); these results are consistent with an influence of these allele variants on the population risk of EC. However, none of these four alleles had a high enough prevalence in Turkomans to explain the high rates of EC in this group. Three of these four alleles (CYP1A1 m1, CYP1A1 m2, CYP2A6*9) were less frequent among Turkomans than in some Asian populations with lower risks of EC. We conclude that it is unlikely that variations in these polymorphic genes are major contributors to the high incidence of EC among Turkomans in Iran.
Authors:
Alireza Sepehr; Farin Kamangar; Christian C Abnet; Saman Fahimi; Akram Pourshams; Hossein Poustchi; Sirous Zeinali; Masood Sotoudeh; Farhad Islami; Dariush Nasrollahzadeh; Reza Malekzadeh; Philip R Taylor; Sanford M Dawsey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  213     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-25     Completed Date:  2004-11-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  195-202     Citation Subset:  IM    
Affiliation:
The US National Cancer Institute, Bethesda, MD, USA.
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MeSH Terms
Descriptor/Qualifier:
Asia / epidemiology
Ecology
Enzymes / genetics
Esophageal Neoplasms / epidemiology,  ethnology*,  genetics*
Genetic Predisposition to Disease*
Genetics, Population*
Humans
Incidence
Iran / epidemiology,  ethnology
Polymorphism, Genetic*
Risk Factors
Chemical
Reg. No./Substance:
0/Enzymes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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