Document Detail

Genetic polymorphisms of hypoxia-inducible factor-1 alpha and cardiovascular disease in hemodialysis patients.
MedLine Citation:
PMID:  19602906     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hemodialysis patients are prone to ischemic events potentially aggravated by hypoxia. The key player in adaptation to hypoxia is hypoxia-inducible factor-1 alpha (HIF-1alpha). Therefore, we investigated the association of HIF-1alpha polymorphisms with ischemia/hypoxia-related events in hemodialysis patients. METHODS: Patients on maintenance hemodialysis were enrolled from 4 training hospitals in Korea. Seven single nucleotide polymorphisms (SNP) of HIF-1alpha were genotyped. The association of these SNP with hypoxia-related clinical outcomes (ischemic diseases and anemia) and cancer was analyzed. RESULTS: A total of 376 patients participated in the study. No significant difference in genotype distribution was found between subjects with and without the hypoxia-related events. Three sets of linkage disequilibrium blocks were made for haplotype analyses (rs2783778 and rs7148720 in 5' upstream region; rs7143164 and rs10873142; rs2301113, rs11549465 and rs2057482). Of these, the CT haplotype in the first set was associated with both acute myocardial infarction and frequent intradialytic hypotension (acute myocardial infarction: adjusted odds ratio = 0.15, 95% CI: 0.03-0.69; frequent intradialytic hypotension: adjusted odds ratio = 0.29, 95% CI: 0.12-0.72). CONCLUSION: Genetic polymorphisms of HIF-1alpha were associated with acute myocardial infarction and intradialytic hypotension in hemodialysis patients.
Zhen Lon Zheng; Young-Hwan Hwang; Seong Kyun Kim; Sejoong Kim; Min Jung Son; Han Ro; Su-Ah Sung; Hyun Hee Lee; Woo Kyung Chung; Kwon Wook Joo; Jaeseok Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-14
Journal Detail:
Title:  Nephron. Clinical practice     Volume:  113     ISSN:  1660-2110     ISO Abbreviation:  Nephron Clin Pract     Publication Date:  2009  
Date Detail:
Created Date:  2009-09-24     Completed Date:  2009-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101159763     Medline TA:  Nephron Clin Pract     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  c104-11     Citation Subset:  IM    
Department of Internal Medicine, Gachon University of Medicine and Science, Incheon, Korea.
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MeSH Terms
Aged, 80 and over
Cardiovascular Diseases / epidemiology*,  genetics*
Genetic Predisposition to Disease / epidemiology,  genetics
Hypoxia-Inducible Factor 1, alpha Subunit / genetics*
Kidney Failure, Chronic / epidemiology,  genetics*,  rehabilitation*
Korea / epidemiology
Middle Aged
Polymorphism, Single Nucleotide / genetics*
Renal Dialysis / utilization*
Risk Assessment / methods
Risk Factors
Young Adult
Reg. No./Substance:
0/HIF1A protein, human; 0/Hypoxia-Inducible Factor 1, alpha Subunit

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