Document Detail


Genetic polymorphisms among Iranian Jews in Israel.
MedLine Citation:
PMID:  6945044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iranian Jews represent a very ancient Jewish community with a high frequency of inbreeding. A sample of Iranian Jews, mainly unrelated students, was tested for genetic markers of red blood cells and serum. The frequency of glucose-6-phosphate dehydrogenase deficiency was not uniform among Jews who had lived in different areas of Iran; it was lower among those from central Iran (6.7%) than in those from southern and western Iran (16.7% and 20.6%, respectively). The frequencies of B, CDe, cDE, S, and K alleles were among the highest recorded in Jewish ethnic groups. Iranian Jews were similar to Iraqi Jews with respect to the frequencies of the blood markers B, CDe, cde, cDe, ACP, PGM1, ADA, and Hp; however, the B and CDe markers occur with similar frequencies among indigenous Iranians. The presence of the cDe allele and the Gm1,5,13,14,17 haplotype in low frequencies indicates black admixture. Mongoloid admixture is indicated by the polymorphism of the Gm1,13,15,16,17 haplotype. The very rare phenotype Gm(3,5,13,14,17) was observed in 4.8% of 167 individuals tested. This phenotype has not been previously observed among Jews.
Authors:
T Cohen; B Simhai; A G Steinberg; C Levene
Related Documents :
20713184 - A large, systematic molecular-genetic study of g6pd in indian populations identifies a ...
8629104 - Medical genetics in singapore.
18558634 - Coexpression of gene polymorphisms involved in bilirubin production and metabolism.
6945044 - Genetic polymorphisms among iranian jews in israel.
20838034 - Mutations of the sry-responsive enhancer of sox9 are uncommon in xy gonadal dysgenesis.
22726844 - A common variant in slc8a1 is associated with the duration of the electrocardiographic ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of medical genetics     Volume:  8     ISSN:  0148-7299     ISO Abbreviation:  Am. J. Med. Genet.     Publication Date:  1981  
Date Detail:
Created Date:  1981-11-22     Completed Date:  1981-11-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7708900     Medline TA:  Am J Med Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  181-90     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Blood Group Antigens / genetics
Consanguinity
Female
Genetic Markers
Glucosephosphate Dehydrogenase / genetics
Haptoglobins / genetics
Hemoglobins / genetics
Humans
Immunoglobulin Allotypes / genetics
Iran / ethnology
Isoenzymes / genetics
Israel
Jews*
Male
Polymorphism, Genetic*
Grant Support
ID/Acronym/Agency:
GM-07214/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Blood Group Antigens; 0/Genetic Markers; 0/Haptoglobins; 0/Hemoglobins; 0/Immunoglobulin Allotypes; 0/Isoenzymes; EC 1.1.1.49/Glucosephosphate Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Stability of anthracycline antitumor agents in four infusion fluids.
Next Document:  A simpler approach to labor induction using lipid-based prostaglandin E2 vaginal suppository.