| Genetic polymorphism of paraoxonase and the risk of coronary heart disease. | |
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MedLine Citation:
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PMID: 9194756 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent studies have implicated paraoxonase, an HDL-associated enzyme, in providing protection against LDL oxidation, thus affecting the risk of coronary heart disease (CHD) in the general population. In this study, we evaluated the distribution of a biallelic PON polymorphism at codon 192 (A and B alleles) and its relationship with plasma lipids and CHD in two racial groups comprising Asian Indians and Chinese from Singapore. The frequency of the B allele was significantly higher in Chinese control subjects than in Indian control subjects (0.58 versus 0.33; P < .0001). With the exception of a marginal effect on apolipoprotein A-I levels in Indians, no other significant association was observed between the PON polymorphism and quantitative lipid traits in either racial group. However, there was a race-specific association of the B allele with CHD in Indians but not in Chinese. The Indian CHD patients had a significantly higher frequency of the B allele than control subjects (.43 versus .33; P = .014). The age- and sex-adjusted odds ratio for developing CHD with the B allele (BB+AB genotypes) was 2.01 (95% CI, 1.17 to 3.45; P = .011) compared with the A allele (AA genotype). When the Indian patients were stratified into subgroups, the association remained significant in nondiabetic patients (odds ratio, 2.29; P = .008), and it became stronger in patients with myocardial infarction (odds ratio, 2.94; P = .004) than in patients without myocardial infarction (odds ratio, 1.11; P = .76). These data indicate that a common polymorphism in the PON gene is an independent risk factor for CHD in populations with white ancestry. |
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Authors:
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D K Sanghera; N Saha; C E Aston; M I Kamboh |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 17 ISSN: 1079-5642 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-07-10 Completed Date: 1997-07-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1067-73 Citation Subset: IM |
Affiliation:
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Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aryldialkylphosphatase China / ethnology Coronary Disease / genetics* Esterases / genetics* Female Gene Frequency Humans India / ethnology Male Middle Aged Odds Ratio Polymorphism, Genetic Regression Analysis Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL-44672/HL/NHLBI NIH HHS; HL-49074/HL/NHLBI NIH HHS; HL-52611/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.1.-/Esterases; EC 3.1.8.1/Aryldialkylphosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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