Document Detail

Genetic polymorphism of STAT5A protein: relationships with production traits and milk composition in Italian Brown cattle.
MedLine Citation:
PMID:  19638264     Owner:  NLM     Status:  MEDLINE    
STATs are a group of transcription factors that mediate actions of a variety of peptide hormones and cytokines within target cells (for example, prolactin and growth hormone). Therefore, STAT5A gene is a candidate marker for quantitative traits in farm animals with respect to milk production traits. In this study the STAT5A/AvaI polymorphism was investigated with PCR-RFLP in a sample of 233 Italian Brown cattle. This polymorphism is localized in the coding region of the bovine STAT5A gene. It is a substitution C-->T at position 6853 within exon 7. All three possible genotypes for the C/T polymorphism were identified. The overall frequencies of alleles C and T were 0.83 and 0.17 respectively; the Hardy-Weinberg equilibrium was verified. In order to study the relationship between STAT5A/AvaI polymorphism and milk performance traits, the data for a 305-d milk production that included milk yield, protein and fat yield, fat and protein percentage were used. Significant differences between the two genotypes were found in yields of milk, fat and protein and protein percentage (P<0.01). CC cows produced more milk than CT (5418.68 v. 5149.54 kg). Protein content was higher in milk from CC compared with CT genotypes (3.40 v. 3.21%). No significant difference was found in fat content. Owing to the low number of TT cows in the studied population, this genotype was not included in the statistical analysis; in fact the number of TT cows was not enough to provide an accurate statistical analysis. Although more studies are needed to better clarify the role of this SNP on production traits, STAT5A/AvaI polymorphism appears to be a promising indirect marker to improve milk production traits in cattle.
Maria Selvaggi; Cataldo Dario; Giovanni Normanno; Gaetano V Celano; Marco Dario
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Publication Detail:
Type:  Journal Article     Date:  2009-07-29
Journal Detail:
Title:  The Journal of dairy research     Volume:  76     ISSN:  1469-7629     ISO Abbreviation:  J. Dairy Res.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-14     Completed Date:  2009-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985125R     Medline TA:  J Dairy Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  441-5     Citation Subset:  IM    
Department of Animal Health and Welfare, University of Study of Bari, strada prov. le per Casamassima Km 3-70010 Valenzano, Italy.
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MeSH Terms
Cattle / genetics*,  physiology*
Gene Expression Regulation / physiology
Genetic Markers
Lactation / genetics*
Milk / chemistry*
Polymorphism, Genetic*
STAT5 Transcription Factor / genetics,  metabolism*
Reg. No./Substance:
0/Genetic Markers; 0/STAT5 Transcription Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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