Document Detail


Genetic polymorphism of the 3' VNTR region of the human dopaminergic function gene DAT1 (human dopamine transporter gene) in the Mongolian population.
MedLine Citation:
PMID:  8754257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hypervariable region of the dopamine transporter gene (DAT1) was amplified from samples in the Mongolian population. This region includes a variable number of tandem repeats of a 40-bp core unit in the 3' untranslated region of DAT1. Vandenbergh et al. (1992) reported variability in the number of repeats of this 3' flanking region ranging from 3 to 11 times in white and black populations. We examined polymorphism at the DAT1 locus in 78 native Mongolian subjects. We found alleles with 7 to 13 repeats, which is different from the findings of Vandenbergh et al. (1992). The allele distribution of the Mongolian population is similar to that in the Japanese population, reported previously by Nakatome et al. (1995). Chi-square analysis showed a significant lack of homogeneity between our findings in Mongolian subjects and those reported previously in white and black populations. The DAT1 locus was estimated to have a heterozygosity index of 14.1%, and the polymorphic information content was calculated to be 0.16.
Authors:
M Nakatome; K Honda; Z Tun; Y Kato; S Harihara; K Omoto; S Misawa; T Gerelsaikhan; S Nyamkhishig; B Dashnyam; J Batsuuri; C Wakasugi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human biology     Volume:  68     ISSN:  0018-7143     ISO Abbreviation:  Hum. Biol.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-09-19     Completed Date:  1996-09-19     Revised Date:  2011-04-18    
Medline Journal Info:
Nlm Unique ID:  0116717     Medline TA:  Hum Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  509-15     Citation Subset:  IM    
Affiliation:
Department of Legal Medicine, Osaka University Medical School, Japan.
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
Carrier Proteins / genetics*
Chi-Square Distribution
Dopamine Plasma Membrane Transport Proteins
Gene Frequency
Humans
Membrane Glycoproteins*
Membrane Transport Proteins*
Minisatellite Repeats / genetics*
Molecular Sequence Data
Mongolia
Nerve Tissue Proteins*
Polymorphism, Genetic*
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Dopamine Plasma Membrane Transport Proteins; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/Nerve Tissue Proteins; 0/SLC6A3 protein, human

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