Document Detail


Genetic and pathologic evolution of early secondary gliosarcoma.
MedLine Citation:
PMID:  23324827     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Gliosarcoma is a subset of glioblastoma with glial and mesenchymal components. True secondary gliosarcomas (i.e. progressing from lower-grade precursors) in the absence of radiation therapy are very rare. We report the unique case of a 61-year-old male who developed a fibrillary astrocytoma (WHO grade II). In the absence of adjuvant therapy the tumor recurred 3 years later as a gliosarcoma comprising an infiltrating glial component and a curious, early high-grade sarcomatous component surrounding intratumoral vessels. DNA was extracted from formalin fixed paraffin-embedded tissues from the precursor low-grade glioma and from the glioma and sarcomatous components at progression. Samples were hybridized separately to a 300 k Illumina SNP array. IDH1(R132H) mutant protein immunohistochemistry was positive in all tissue components. Alterations identified in all samples included dup(1)(q21q41), del(1)(q41qter), del(2)(q31.1), del(2)(q36.3qter), del(4)(q35.1qter), dup(7)(q22.2q36.3), del(7)(q36.3qter), del(9)(p21.3pter), dup(10)(p13pter), del(10)(q26.13q26.3), dup(17) (q12qter), and copy neutral LOH(20)(p11.23p11.21). The recurrent tumor had additional alterations, including del(3)(p21.31q13.31), del(18)(q21.2qter), and a homozygous del(9)(p21.3)(CDKN2A locus) and the sarcoma component had, in addition, del(4)(p14pter), del(6)(q12qter), del(11)(q24.3qter), and del(16)(p11.2pter). In conclusion, unique copy number alterations were identified during tumor progression from a low-grade glioma to gliosarcoma. A subset of alterations developed specifically in the sarcomatous component.
Authors:
Kari-Elise T Codispoti; Stacy Mosier; Robert Ramsey; Ming-Tseh Lin; Fausto J Rodriguez
Related Documents :
24351217 - Is there a role for apparent diffusion coefficients in the differential diagnosis of br...
23774157 - Congenital osteofibrous dysplasia campanacci: spontaneous postbioptic regression.
23076857 - Malignant ossifying fibromyxoid tumor of the parapharyngeal space.
23455797 - Postchemotherapy-related changes in mediastinal mixed germ cell tumor masquerading as a...
14758047 - Antiproliferative activity of the main constituents from phyllanthus emblica.
18776537 - Thymidine phoshorylase as a target for antiangiogenesis treatment.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Brain tumor pathology     Volume:  -     ISSN:  1861-387X     ISO Abbreviation:  Brain Tumor Pathol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9716507     Medline TA:  Brain Tumor Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pathology, Johns Hopkins University, Baltimore, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Turn-on colorimetric sensor for ultrasensitive detection of thrombin using fibrinogen-gold nanoparti...
Next Document:  Pd-catalyzed decarboxylative ortho-acylation of O-methyl oximes with phenylglyoxylic acids.