| Genetic origin of malignant trophoblastic neoplasms analyzed by sequence tag site polymorphic markers. | |
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MedLine Citation:
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PMID: 11330958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the causative conception of malignant gestational trophoblastic neoplasms (GTNs), we analyzed malignant GTNs by microsatellite PCR markers. METHOD: DNAs extracted from 12 malignant GTNs were subjected to PCR for five different chromosomal locations. RESULT: Of the 7 cases after a complete mole (CM), 5 were derived from androgenesis, but the remaining 2 were from normal fertilization. Of the 5 cases after nonmolar pregnancies, 2 placental site trophoblastic tumors had alleles from both parents. Of the other 3 choriocarcinomas, 1 was from normal fertilization after spontaneous abortion but 2 originated from androgenesis, suggesting that 1 was from a CM prior to the antecedent abortion, transforming after a long interval. CONCLUSION: By combining the previous cases with these, our analysis of 39 cases demonstrated that trophoblastic neoplasms can arise from at least three different modes of origin (androgenesis, normal fertilization, and parthenogenesis), and antecedent pregnancy is not always identical to the causative conception. Placental site trophoblastic tumors might have different machinery for carcinogenesis because of the predominance of paternal and maternal contributions. In addition, a long dormancy of trophoblasts before malignant transformation, especially for those originating from normal fertilization, was also suggested. |
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Authors:
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N Shahib; D Martaadisoebrata; H Kondo; Y Zhou; N Shinkai; C Nishimura; K Kiyoko; T Matsuda; N Wake; H D Kato |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gynecologic oncology Volume: 81 ISSN: 0090-8258 ISO Abbreviation: Gynecol. Oncol. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-05-01 Completed Date: 2001-05-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0365304 Medline TA: Gynecol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 247-53 Citation Subset: IM |
Copyright Information:
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Copyright 2001 Academic Press. |
Affiliation:
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Department of Obstetrics & Gynecology, Padjadjaran University Hansan Sadikin Hospital, 38 Jalan Pasteur, Bandung 40161, Indonesia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Hydatidiform Mole / genetics Microsatellite Repeats / genetics* Polymerase Chain Reaction Polymorphism, Genetic* Pregnancy Sequence Tagged Sites* Trophoblastic Neoplasms / genetics* Uterine Neoplasms / genetics* |
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