| Genetic optimization of recombinant glycoprotein production by mammalian cells. | |
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MedLine Citation:
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PMID: 10098276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Genetically modified mammalian cells are the preferred system for the production of recombinant therapeutic glycoproteins. Other applications include engineering of cell lines for drug screening and cell-based therapies, and the construction of recombinant viruses for gene therapy. This article highlights contemporary core genetic technologies and emerging strategies for genetically engineering mammalian cells for optimal recombinant-protein expression. |
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Authors:
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M Fussenegger; J E Bailey; H Hauser; P P Mueller |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Trends in biotechnology Volume: 17 ISSN: 0167-7799 ISO Abbreviation: Trends Biotechnol. Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-05-06 Completed Date: 1999-05-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8310903 Medline TA: Trends Biotechnol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 35-42 Citation Subset: IM |
Affiliation:
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Institute of Biotechnology, ETH Hönggerberg, Zurich, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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genetics Gene Expression Regulation Genes / genetics Glycoproteins / biosynthesis* Glycosylation Molecular Biology / methods* Protein Engineering / methods* Protein Processing, Post-Translational Recombinant Proteins / biosynthesis, isolation & purification Recombination, Genetic Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Glycoproteins; 0/Recombinant Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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