| Genetic monitoring of aluminum workers exposed to coal tar pitch volatiles. | |
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MedLine Citation:
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PMID: 3974629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A group of 50 workers exposed to coal tar pitch volatiles (CTPV) in an aluminum reduction plant and a group of 50 non-exposed workers were selected to evaluate the genotoxic effects of CTPV exposure. A battery of tests was performed on 3 different body fluids; urine, blood and semen. Urine samples were evaluated for mutagenic constituents using the Ames/Salmonella assay. Cultured lymphocytes from blood samples were used to perform cytogenetic analysis. Semen samples were used to measure sperm count, percent abnormal sperm morphology and frequency of sperm carrying double fluorescent bodies (2-F). 14 of 28 (50%) exposed workers and 7 of 36 (19.4%) non-exposed workers had mutagenic urine. This difference was significant (p less than 0.01). Among the non-smokers a significantly higher percentage of workers who were exposed had positive urine (36%) compared to the non-exposed workers (5%) (p less than 0.05). Among the exposed group, more mechanics had mutagenic urine than did other types of workers. Overall chromosome aberration rates were similar in both exposed and non-exposed workers. Among exposed workers a significant inverse correlation (p less than 0.05) between age and chromatid aberration rate was observed. Results of semen analysis failed to detect differences between exposed and non-exposed workers. Results of these tests lend support to a battery approach to genetic monitoring and suggest a link between exposure to CTPV and genotoxic effects. Detection of exposure to mutagens at an early time offers an opportunity for disease prevention by the reduction of exposure. |
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Authors:
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J C Heussner; J B Ward; M S Legator |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mutation research Volume: 155 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1985 Mar |
Date Detail:
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Created Date: 1985-04-08 Completed Date: 1985-04-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 143-55 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aluminum Chromosome Aberrations* Coal Tar / pharmacology* Environmental Exposure Humans Lymphocytes / ultrastructure Male Mass Screening Metallurgy* Middle Aged Mutagenicity Tests Occupational Diseases / prevention & control Polycyclic Compounds / pharmacology* Semen / analysis Urine / analysis Volatilization |
| Chemical | |
Reg. No./Substance:
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0/Polycyclic Compounds; 7429-90-5/Aluminum; 8007-45-2/Coal Tar |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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