Document Detail

Genetic markers may predict disease behavior in patients with ulcerative colitis.
MedLine Citation:
PMID:  9178675     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: Recent studies have suggested that HLA DRB1*0103 and allele 2 of the interleukin 1 receptor antagonist (IL-1RA) gene predict severe and extensive ulcerative colitis, respectively. The aim of this study was to test these hypotheses in patients undergoing surgery for their colitis. METHODS: HLA DRB1 and DQB1 genotyping was performed in 99 patients and 472 controls. Genotyping for polymorphisms of genes encoding tumor necrosis factor alpha and IL-1RA was performed in 107 patients and 89 controls. Measurement of antineutrophil cytoplasmic antibody (ANCA) was performed in 72 patients and 58 healthy subjects by fixed neutrophil enzyme-linked immunosorbent assay and indirect immunofluorescence. RESULTS: The DRB1*0103 allele was increased in patients (14.1% vs. 3.2% in controls; P < 1 x 10[-5]). This association was greatest in patients with extensive disease (15.8%; P < 0.0001) or extraintestinal manifestations (22.8%; P < 0.0001): mouth ulcers (25.8%; P < 0.0001), arthritis (27.2%; P < 0.0001), and uveitis (35.7%; P < 0.0001). The DRB1*04 alleles were reduced in patients (P = 0.005). Differences were noted between extensive and distal disease in the frequency of allele 2 of IL-1RA (10.9% in distal vs. 28.6% in extensive; P = 0.01) and allele 2 homozygosity. ANCA was detected in 76.4% of patients. Carriage of IL-1RA allele 2 and tumor necrosis factor 2 allele was increased in ANCA-positive patients. CONCLUSIONS: Genetic markers may predict disease behavior in ulcerative colitis.
M Roussomoustakaki; J Satsangi; K Welsh; E Louis; G Fanning; S Targan; C Landers; D P Jewell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterology     Volume:  112     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-07-21     Completed Date:  1997-07-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1845-53     Citation Subset:  AIM; IM    
Nuffield Department of Medicine, Radcliffe Hospitals, Oxford, England.
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MeSH Terms
Antibodies, Antineutrophil Cytoplasmic / metabolism*
Colitis, Ulcerative / genetics*
Genetic Markers
Middle Aged
Reg. No./Substance:
0/Antibodies, Antineutrophil Cytoplasmic; 0/Genetic Markers

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