Document Detail


Genetic markers of fibrinolytic responses of older persons to exercise training.
MedLine Citation:
PMID:  16874588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We assessed the interactive effect of genetic polymorphisms and exercise training on fibrinolysis in 50 - 75 yr old men (n = 17) and women (n = 28). Subjects had tissue plasminogen activator (t-PA) antigen levels and activity and plasminogen activator inhibitor-1 (PAI-1) activity measured before and after 6 mo of endurance-exercise training. Subject's DNA was typed for the PAI-1 4 G/5 G and t-PA I/D variants. Baseline PAI-1 activity, t-PA activity, and t-PA antigen levels were not different among PAI-1 or t-PA genotype groups. Overall, exercise training did not change PAI-1 activity (- 0.43 +/- 0.81 IU/mL, p = NS), increased t-PA activity (0.37 +/- 0.16 IU/mL, p = 0.02), and decreased t-PA antigen levels (- 0.88 +/- 0.20 ng/mL, p < 0.001). Although the differences in changes with training were not significant among genotype groups, significant t-PA antigen level improvements were evident only in PAI-1 4 G allele carriers and significant t-PA activity increases only in PAI-1 4 G homozygotes. t-PA genotype affected the training-induced t-PA antigen level improvements (p = 0.033) after covarying for gender and baseline t-PA antigen levels, with the smallest and largest reductions in the D homozygotes and I/D heterozygotes, respectively. These findings could have important treatment implications for the use of exercise training to reduce CV disease and thrombotic risk in older men and women.
Authors:
O Kulaputana; I Ghiu; D A Phares; R E Ferrell; R F Macko; A P Goldberg; J M Hagberg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  International journal of sports medicine     Volume:  27     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-28     Completed Date:  2006-10-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  617-22     Citation Subset:  IM    
Affiliation:
Department of Kinesiology, University of Maryland, College Park, 20742, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Antigens / blood
Exercise / physiology*
Female
Fibrinolysis / genetics*,  physiology
Gene Frequency
Genetic Markers
Genotype
Humans
Male
Middle Aged
Plasminogen Activator Inhibitor 1 / blood,  genetics*
Tissue Plasminogen Activator / genetics*,  immunology
Grant Support
ID/Acronym/Agency:
AG15389/AG/NIA NIH HHS; AG17474/AG/NIA NIH HHS; P60 AG12583/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Antigens; 0/Genetic Markers; 0/Plasminogen Activator Inhibitor 1; EC 3.4.21.68/Tissue Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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