| Genetic markers of fibrinolytic responses of older persons to exercise training. | |
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MedLine Citation:
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PMID: 16874588 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We assessed the interactive effect of genetic polymorphisms and exercise training on fibrinolysis in 50 - 75 yr old men (n = 17) and women (n = 28). Subjects had tissue plasminogen activator (t-PA) antigen levels and activity and plasminogen activator inhibitor-1 (PAI-1) activity measured before and after 6 mo of endurance-exercise training. Subject's DNA was typed for the PAI-1 4 G/5 G and t-PA I/D variants. Baseline PAI-1 activity, t-PA activity, and t-PA antigen levels were not different among PAI-1 or t-PA genotype groups. Overall, exercise training did not change PAI-1 activity (- 0.43 +/- 0.81 IU/mL, p = NS), increased t-PA activity (0.37 +/- 0.16 IU/mL, p = 0.02), and decreased t-PA antigen levels (- 0.88 +/- 0.20 ng/mL, p < 0.001). Although the differences in changes with training were not significant among genotype groups, significant t-PA antigen level improvements were evident only in PAI-1 4 G allele carriers and significant t-PA activity increases only in PAI-1 4 G homozygotes. t-PA genotype affected the training-induced t-PA antigen level improvements (p = 0.033) after covarying for gender and baseline t-PA antigen levels, with the smallest and largest reductions in the D homozygotes and I/D heterozygotes, respectively. These findings could have important treatment implications for the use of exercise training to reduce CV disease and thrombotic risk in older men and women. |
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Authors:
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O Kulaputana; I Ghiu; D A Phares; R E Ferrell; R F Macko; A P Goldberg; J M Hagberg |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: International journal of sports medicine Volume: 27 ISSN: 0172-4622 ISO Abbreviation: Int J Sports Med Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-07-28 Completed Date: 2006-10-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8008349 Medline TA: Int J Sports Med Country: Germany |
Other Details:
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Languages: eng Pagination: 617-22 Citation Subset: IM |
Affiliation:
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Department of Kinesiology, University of Maryland, College Park, 20742, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antigens / blood Exercise / physiology* Female Fibrinolysis / genetics*, physiology Gene Frequency Genetic Markers Genotype Humans Male Middle Aged Plasminogen Activator Inhibitor 1 / blood, genetics* Tissue Plasminogen Activator / genetics*, immunology |
| Grant Support | |
ID/Acronym/Agency:
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AG15389/AG/NIA NIH HHS; AG17474/AG/NIA NIH HHS; P60 AG12583/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Genetic Markers; 0/Plasminogen Activator Inhibitor 1; EC 3.4.21.68/Tissue Plasminogen Activator |
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