Document Detail


Genetic markers of IgG influence the outcome of infection with hepatitis C virus.
MedLine Citation:
PMID:  18855559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the role that immunoglobulin GM and KM allotypes-genetic markers of gamma and kappa chains, respectively-play in the outcome of hepatitis C virus (HCV) infection in white Americans. A total of 119 persons who had cleared HCV and 111 with persistent HCV infection were genotyped for the presence of several GM and KM determinants. Persistent HCV infection was more than three times as likely (odds ratio, 3.50; P= .01) in subjects who were carriers of the GM3 allele than in those who were noncarriers. These results show that particular GM alleles may be important determinants of the outcome of HCV infection.
Authors:
Janardan P Pandey; Aryan M Namboodiri; Yuqun Luo; Yuping Wu; Robert C Elston; David L Thomas; Hugo R Rosen; James J Goedert
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  198     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-15     Completed Date:  2008-12-09     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1334-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Genetic Markers
Genetic Predisposition to Disease
Genotype
Hepacivirus / immunology
Hepatitis C / genetics*,  immunology
Humans
Immunoglobulin G / genetics*
Immunoglobulin Gm Allotypes / genetics
Immunoglobulin Km Allotypes / genetics
Grant Support
ID/Acronym/Agency:
DA13224/DA/NIDA NIH HHS; DK070877/DK/NIDDK NIH HHS; HG003054/HG/NHGRI NIH HHS; R01 DA013324/DA/NIDA NIH HHS; R01 DA013324-01/DA/NIDA NIH HHS; R01 DA013324-02/DA/NIDA NIH HHS; R01 DA013324-03/DA/NIDA NIH HHS; R01 DA013324-04/DA/NIDA NIH HHS; R01 DA013324-05/DA/NIDA NIH HHS; R01 DA013324-05S1/DA/NIDA NIH HHS; R01 DA013324-06/DA/NIDA NIH HHS; R01 DA013324-07/DA/NIDA NIH HHS; R01 DA013324-08/DA/NIDA NIH HHS; R01 DA013324-09/DA/NIDA NIH HHS; R01 DK070877-01A1/DK/NIDDK NIH HHS; R01 DK070877-02/DK/NIDDK NIH HHS; R01 DK070877-03/DK/NIDDK NIH HHS; R01 HG003054/HG/NHGRI NIH HHS; R01 HG003054-01A1/HG/NHGRI NIH HHS; R01 HG003054-02/HG/NHGRI NIH HHS; R01 HG003054-03/HG/NHGRI NIH HHS; R01 HG003054-04/HG/NHGRI NIH HHS; Z01 CP010176-05/CP/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers; 0/Immunoglobulin G; 0/Immunoglobulin Gm Allotypes; 0/Immunoglobulin Km Allotypes
Comments/Corrections

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