| Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. | |
| | |
MedLine Citation:
|
PMID: 1655275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The stroke-prone spontaneously hypertensive rat (SHRSP) is a well-characterized model for primary hypertension in humans. High blood pressure in SHRSP shows polygenic inheritance, but none of the loci responsible have previously been identified. To locate genes controlling this quantitative trait, we mapped a large collection of DNA polymorphisms in a cross between SHRSP and the normotensive WKY strain. Here we report strong genetic evidence that a gene, Bp1, having a major effect on blood pressure maps to rat chromosome 10 with a LOD score of 5.10 and is closely linked to the rat gene encoding angiotensin-converting enzyme (ACE), an enzyme that plays a major role in blood pressure homeostasis and is an important target of anti-hypertensive drugs. We also find significant, albeit weaker, linkage to a locus, Bp2, on chromosome 18. We discuss the implications of genetic dissection of quantitative disease-related phenotypes in mammals. |
| | |
Authors:
|
H J Jacob; K Lindpaintner; S E Lincoln; K Kusumi; R K Bunker; Y P Mao; D Ganten; V J Dzau; E S Lander |
Related Documents
:
|
21526095 - Assessment of antioxidant enzyme activities in erythrocytes of pre-hypertensive and hyp... 15480095 - The glu27 allele of the beta2 adrenergic receptor increases the risk of cardiac hypertr... 15536455 - Effects of systemic endothelin a receptor antagonism in various vascular beds in men: i... 8420305 - Genetics of essential hypertension. 21154265 - Effect of l-arginine or l-citrulline oral supplementation on blood pressure and right v... 11415705 - Transformation and average as handy tools for pressure measurement data analysis. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Cell Volume: 67 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 1991 Oct |
Date Detail:
|
Created Date: 1991-11-07 Completed Date: 1991-11-07 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0413066 Medline TA: Cell Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 213-24 Citation Subset: IM |
Affiliation:
|
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Base Sequence Blood Pressure Cerebrovascular Disorders / genetics* Chromosome Mapping* Crosses, Genetic Female Genotype Hypertension / genetics*, physiopathology Linkage (Genetics) Lod Score Male Molecular Sequence Data Oligodeoxyribonucleotides Peptidyl-Dipeptidase A / genetics* Rats Rats, Inbred SHR / genetics* Rats, Inbred WKY / genetics Repetitive Sequences, Nucleic Acid |
| Grant Support | |
ID/Acronym/Agency:
|
HG00198/HG/NHGRI NIH HHS; HL35610/HL/NHLBI NIH HHS; HL42663/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Oligodeoxyribonucleotides; EC 3.4.15.1/Peptidyl-Dipeptidase A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The cdc25 protein contains an intrinsic phosphatase activity.
Next Document: The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle.