Document Detail


Genetic mapping of a cloned sequence responsible for susceptibility to ecotropic murine leukemia viruses.
MedLine Citation:
PMID:  2159567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A mouse cDNA that confers susceptibility to ecotropic murine leukemia viruses following transfection into human EJ cells has been cloned and sequenced. We show that this sequence is likely to be Rec-1, the chromosome 5 locus originally defined by studies with somatic cell hybrids as responsible for virus susceptibility, and provide a specific chromosomal map position for this locus by analysis of an interspecies backcross. This locus maps in the distal region of chromosome 5 and is thus not within the cluster of retrovirus-related genes near the centromere.
Authors:
C A Kozak; L M Albritton; J Cunningham
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of virology     Volume:  64     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-06-14     Completed Date:  1990-06-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3119-21     Citation Subset:  IM    
Affiliation:
National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blotting, Southern
Cell Line
Chromosome Mapping*
Cloning, Molecular
DNA / genetics*,  isolation & purification
Genetic Predisposition to Disease
Humans
Hybrid Cells
Leukemia Virus, Murine / pathogenicity*
Leukemia, Experimental / genetics*,  microbiology
Mice
Molecular Weight
Receptors, Virus / genetics
Recombination, Genetic
Transfection
Chemical
Reg. No./Substance:
0/Receptors, Virus; 9007-49-2/DNA
Comments/Corrections

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