Document Detail


Genetic mapping of GLCLC, the human gene encoding the catalytic subunit of gamma-glutamyl-cysteine synthetase, to chromosome band 6p12 and characterization of a polymorphic trinucleotide repeat within its 5' untranslated region.
MedLine Citation:
PMID:  8995480     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The first and rate-limiting step in the formation of glutathione is catalyzed by gamma-glutamylcysteine synthetase (glutamate-cysteine ligase, E.C. 6.3.2.2). Herein, we describe a trinucleotide repeat polymorphism located in the 5' untranslated region of the human gene, GLCLC, that encodes the catalytic subunit of this enzyme, and we genetically map GLCLC to band 6p12, 1.6 cM distal to D6S295.
Authors:
A C Walsh; W Li; D R Rosen; D A Lawrence
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cytogenetics and cell genetics     Volume:  75     ISSN:  0301-0171     ISO Abbreviation:  Cytogenet. Cell Genet.     Publication Date:  1996  
Date Detail:
Created Date:  1997-01-30     Completed Date:  1997-01-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0367735     Medline TA:  Cytogenet Cell Genet     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  14-6     Citation Subset:  IM    
Affiliation:
Laboratory of Environmental and Clinical Immunology, Wadsworth Center, New York State Department of Health, Albany 12201-0509, USA. walsh@wadsworth.ph.albany.edu
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MeSH Terms
Descriptor/Qualifier:
Alleles
Chromosome Mapping
Chromosomes, Human, Pair 6*
Glutamate-Cysteine Ligase / deficiency,  genetics*
Humans
Linkage (Genetics)
Polymorphism, Genetic*
Protein Biosynthesis
Trinucleotide Repeats*
Grant Support
ID/Acronym/Agency:
HG00008/HG/NHGRI NIH HHS; R01-ES03778/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
EC 6.3.2.2/Glutamate-Cysteine Ligase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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