| Genetic isolation of a blood pressure quantitative trait locus on chromosome 2 in the spontaneously hypertensive rat. | |
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MedLine Citation:
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PMID: 11403354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Total genome scans of genetically segregating populations derived from the spontaneously hypertensive rat (SHR) and other rat models of hypertension have suggested the presence of quantitative trait loci (QTL) regulating blood pressure and cardiac mass on multiple chromosomes, including chromosome 2. The objective of the current study was to directly test for the presence of a blood pressure QTL on rat chromosome 2. DESIGN: A new congenic strain was derived by replacing a segment of chromosome 2 in the SHR between D2Rat171 and D2Arb24 with the corresponding chromosome segment from the normotensive Brown Norway rat. Arterial pressures were directly monitored in conscious rats by radiotelemetry. RESULTS: We found that the SHR congenic strain (SHR-2) carrying a segment of chromosome 2 from the Brown Norway rat had significantly lower systolic and diastolic blood pressures than the SHR progenitor strain. The attenuation of hypertension in the SHR-2 congenic strain versus the SHR progenitor strain was accompanied by significant amelioration of cardiac hypertrophy. CONCLUSIONS: These findings demonstrate that gene(s) with major effects on blood pressure exist in the differential segment of chromosome 2 trapped within the new SHR.BN congenic strain. |
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Authors:
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M Pravenec; V Zídek; A Musilová; J Vorlícek; V Kren; E St Lezin; T W Kurtz |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of hypertension Volume: 19 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-06-13 Completed Date: 2001-12-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 1061-4 Citation Subset: IM |
Affiliation:
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Institute of Physiology and Center for Integrated Genomics, Czech Academy of Sciences, Prague, Czech Republic. pravenec@biomed.cas.cz |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Congenic Blood Pressure / genetics* Chromosome Mapping Chromosomes / genetics Genotype Hemodynamics Hypertension / genetics*, pathology, physiopathology Male Myocardium / pathology Quantitative Trait, Heritable* Rats Rats, Inbred BN Rats, Inbred SHR / genetics* Rats, Inbred WKY |
| Grant Support | |
ID/Acronym/Agency:
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HL56028/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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