Document Detail


Genetic insights into trophoblast differentiation and placental morphogenesis.
MedLine Citation:
PMID:  10873707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The placenta is comprised of an inner vascular network covered by an outer epithelium, called trophoblast, all designed to promote the delivery of nutrients to the fetus. Several specialized trophoblast cell subtypes arise during development to promote this function, including cells that invade the uterus to promote maternal blood flow to the implantation site, and other cells that fuse into a syncytium, expand and fold to increase the surface area for efficient transport. Mutation of many genes in mice results in embryonic mortality or fetal growth restriction due to defects in placental development. Several important principles about placental development have emerged from these studies. First, distinct molecular pathways regulate the differentiation of the various trophoblast cell subtypes. Second, trophoblast proliferation, differentiation and morphogenesis are highly regulated by interactions with adjacent cell types. Finally, the specific classes of mutant phenotypes observed in the placenta of knockout mice resemble those seen in humans that are associated with preeclampsia and intrauterine growth restriction.
Authors:
J C Cross
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  11     ISSN:  1084-9521     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-09-14     Completed Date:  2000-09-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  105-13     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Affiliation:
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and the Departments of Obstetrics & Gynaecology, and Molecular & Medical Genetics, University of Toronto, Toronto, Ontario, M5G 1X5, Canada. cross@mshri.on.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / genetics*,  physiology
Gene Expression Regulation, Developmental / physiology
Humans
Mice
Mice, Knockout
Placenta / cytology,  growth & development*,  metabolism
Transcription Factors / physiology
Trophoblasts / cytology*,  metabolism,  physiology
Chemical
Reg. No./Substance:
0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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