Document Detail


Genetic influences on renin, aldosterone, and the renal excretion of sodium and potassium following volume expansion and contraction in normal man.
MedLine Citation:
PMID:  396249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the influence of hereditary on plasma renin activity (PRA), plasma aldosterone concentrations (PAC), blood pressure, and the renal excretion of sodium and potassium following volume expansion and contraction in normal man, we studied 37 pairs of monozygotic (MZ) and 18 pairs of dizygotic (DZ) twins. Volume expansion was achieved by the intravenous infusion of 2L normal saline; volume contraction was accomplished by a low-sodium diet and 120 mg oral furosemide. The presence of genetic variance was tested by calculating the within pair and among component estimates of genetic variance. Outpatient 24-hour-urine collections suggested that MZ and DZ twins ingested diets similar in sodium and potassium content, and failed to reveal genetic influences on the dietary preferences for these electrolytes. The PRA values suggested heritable influences during both the volume expanded and contracted state with the added stimulus of upright posture. Heritable influences were observed on PAC and were most apparent in the basal state on the day of volume expansion. An influence of heredity on blood pressure was most apparent during volume contraction. Urinary sodium excretion (UNaV), urinary potassium excretion (UKV), fractional excretion of sodium (FENa), and fractional excretion of potassium (FEK) revealed evidence of significant genetic variance under the condition of volume expansion. in that state, systolic blood pressure was directly correlated with PRA, PAC, and inversely with FENa. The data suggest that the renal regulation of sodium and potassium excretion is in part influenced by heritable factors that may in turn contribute to the development of hypertension in some individuals.
Authors:
C E Grim; J Z Miller; F C Luft; J C Christian; M H Weinberger
Related Documents :
3899419 - Effect of hydralazine on serial measurements of exchangeable sodium and blood pressure ...
2931209 - Role of sodium in hypertensive cardiac hypertrophy.
2138699 - Real-time expert-system-based fuzzy control of mean arterial pressure in pigs with sodi...
21649529 - Long-term mmp inhibition by doxycycline exerts divergent effect on ventricular extracel...
8444719 - Effects of 5-hydroxytryptamine and 5-hydroxytryptophan infusion on the human cough reflex.
1706039 - The effect of sodium intake on ventricular performance in healthy men.
20139769 - Office and 24-h ambulatory blood pressure control by treatment in general practice: the...
8909989 - Comparison of responses to histamine by constant-flow and constant-pressure perfusion m...
24039529 - Monitoring of aphid flight activities in seed potato crops in serbia.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  1     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:    1979 Nov-Dec
Date Detail:
Created Date:  1980-06-16     Completed Date:  1980-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  583-90     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aldosterone / blood*
Blood Pressure
Blood Volume
Body Height
Body Weight
Female
Humans
Hypertension, Renal / genetics*,  metabolism
Kidney / metabolism*,  physiology
Male
Potassium / administration & dosage,  metabolism*,  urine
Pregnancy
Renin / blood*
Sodium / administration & dosage,  metabolism*,  urine
Twins
Chemical
Reg. No./Substance:
52-39-1/Aldosterone; 7440-09-7/Potassium; 7440-23-5/Sodium; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Changes in renal vascular sensitivity and arterial pressure associated with sodium intake during lon...
Next Document:  Therapeutic problems after massive blood transfusions