Document Detail

Genetic influences on renin, aldosterone, and the renal excretion of sodium and potassium following volume expansion and contraction in normal man.
MedLine Citation:
PMID:  396249     Owner:  NLM     Status:  MEDLINE    
To investigate the influence of hereditary on plasma renin activity (PRA), plasma aldosterone concentrations (PAC), blood pressure, and the renal excretion of sodium and potassium following volume expansion and contraction in normal man, we studied 37 pairs of monozygotic (MZ) and 18 pairs of dizygotic (DZ) twins. Volume expansion was achieved by the intravenous infusion of 2L normal saline; volume contraction was accomplished by a low-sodium diet and 120 mg oral furosemide. The presence of genetic variance was tested by calculating the within pair and among component estimates of genetic variance. Outpatient 24-hour-urine collections suggested that MZ and DZ twins ingested diets similar in sodium and potassium content, and failed to reveal genetic influences on the dietary preferences for these electrolytes. The PRA values suggested heritable influences during both the volume expanded and contracted state with the added stimulus of upright posture. Heritable influences were observed on PAC and were most apparent in the basal state on the day of volume expansion. An influence of heredity on blood pressure was most apparent during volume contraction. Urinary sodium excretion (UNaV), urinary potassium excretion (UKV), fractional excretion of sodium (FENa), and fractional excretion of potassium (FEK) revealed evidence of significant genetic variance under the condition of volume expansion. in that state, systolic blood pressure was directly correlated with PRA, PAC, and inversely with FENa. The data suggest that the renal regulation of sodium and potassium excretion is in part influenced by heritable factors that may in turn contribute to the development of hypertension in some individuals.
C E Grim; J Z Miller; F C Luft; J C Christian; M H Weinberger
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  1     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:    1979 Nov-Dec
Date Detail:
Created Date:  1980-06-16     Completed Date:  1980-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  583-90     Citation Subset:  IM    
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MeSH Terms
Aldosterone / blood*
Blood Pressure
Blood Volume
Body Height
Body Weight
Hypertension, Renal / genetics*,  metabolism
Kidney / metabolism*,  physiology
Potassium / administration & dosage,  metabolism*,  urine
Renin / blood*
Sodium / administration & dosage,  metabolism*,  urine
Reg. No./Substance:
52-39-1/Aldosterone; 7440-09-7/Potassium; 7440-23-5/Sodium; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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