Document Detail


Genetic influences on premature parturition in an Australian twin sample.
MedLine Citation:
PMID:  10918619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated possible genetic influences on women's liability to preterm birth, using data from a large sample of Australian female twin pairs. In a 1988-90 questionnaire survey, both members of 905 parous twin pairs (579 monozygotic and 326 dizygotic) reported on whether deliveries had been more than two weeks preterm. Tetrachoric twin pair correlations for first birth were rMZ = 0.20+/-0.11 and rDZ = -0.03+/-0.14, and for any birth were rMZ = 0.30+/-0.08 and rDZ = 0.03+/-0.11. Best-fitting models to data contained only additive genetic influences and individual environmental effects. Heritability was 17% for preterm delivery in first pregnancy, and 27% for preterm delivery in any pregnancy. In the former case, however, we could not reject a model without genetic influences. Although our data did not allow for differentiation of the varying aetiologies of premature parturition, results from this exploratory analysis suggest that further investigation of genetic influences on specific reasons for preterm birth is warranted.
Authors:
S A Treloar; G A Macones; L E Mitchell; N G Martin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Twin Study    
Journal Detail:
Title:  Twin research : the official journal of the International Society for Twin Studies     Volume:  3     ISSN:  1369-0523     ISO Abbreviation:  Twin Res     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-11-08     Completed Date:  2000-11-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9815819     Medline TA:  Twin Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  80-2     Citation Subset:  IM    
Affiliation:
Queensland Institute of Medical Research and Joint Genetics Program, The University of Queensland, Brisbane, Australia. sueT@qimr.edu.au
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Australia
Chi-Square Distribution
Diseases in Twins*
Environment
Female
Humans
Least-Squares Analysis
Middle Aged
Models, Genetic
Obstetric Labor, Premature / genetics*
Parity
Pregnancy
Retrospective Studies
Statistics, Nonparametric
Twins, Dizygotic / genetics
Twins, Monozygotic / genetics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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