| Genetic influences on motion sickness susceptibility in adult women: a classical twin study. | |
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MedLine Citation:
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PMID: 17086768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Motion sickness is a common and potentially debilitating condition that characteristically occurs in situations of conflicting sensory input. While the precise stimuli that give rise to this trait are increasingly well characterized, the underlying determinants of individual susceptibility to motion sickness remain unclear. This study uses a classical twin design to assess the influence of genetic and environmental factors. METHODS: A postal survey was conducted in an age-matched sample of 3652 monozygotic (MZ) and dizygotic (DZ) adult female twins selected from the TwinsUK Registry. Study participants were asked to complete items from a validated questionnaire relating to their lifetime susceptibility to motion sickness. The relative contribution of genetic and environmental factors to motion sickness susceptibility was assessed using variance components analysis. RESULTS: The response rate to the questionnaire was 78%. Approximately 40% of respondents reported at least moderate susceptibility to motion sickness. The pattern of responses among twins indicated a significant genetic contribution with heritability for a motion sickness factor score estimated as 57% (95% CI: 51%, 63%). The heritability of recalled motion sickness was at its highest in childhood (70% [59%, 80%]) and declined through puberty and the early adult years. DISCUSSION AND CONCLUSIONS: The findings highlight the importance of genetic factors in determining an individual's underlying propensity to motion sickness and should stimulate the search for specific susceptibility genes. |
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Authors:
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Caroline M Reavley; John F Golding; Lynn F Cherkas; Tim D Spector; Alex J MacGregor |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Twin Study |
Journal Detail:
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Title: Aviation, space, and environmental medicine Volume: 77 ISSN: 0095-6562 ISO Abbreviation: Aviat Space Environ Med Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-11-07 Completed Date: 2007-01-17 Revised Date: 2007-08-13 |
Medline Journal Info:
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Nlm Unique ID: 7501714 Medline TA: Aviat Space Environ Med Country: United States |
Other Details:
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Languages: eng Pagination: 1148-52 Citation Subset: IM; S |
Affiliation:
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Twin Research and Genetic Epidemiology Unit, Kings College, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Diseases in Twins / genetics* Factor Analysis, Statistical Female Genetic Predisposition to Disease* Humans Middle Aged Motion Sickness / genetics* Questionnaires |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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