Document Detail


Genetic influence on variation in serum uric acid in American Indians: the strong heart family study.
MedLine Citation:
PMID:  19590895     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hyperuricemia is associated with the metabolic syndrome, gout, renal and cardiovascular disease (CVD). American Indians have high rates of CVD and 25% of individuals in the strong heart family study (SHFS) have high serum uric acid levels. The aim of this study was to investigate the genetic determinants of serum uric acid variation in American Indian participants of the SHFS. A variance component decomposition approach (implemented in SOLAR) was used to conduct univariate genetic analyses in each of three study centers and the combined sample. Serum uric acid was adjusted for age, sex, age x sex, BMI, estimated glomerular filtration rate, alcohol intake, diabetic status and medications. Overall mean +/- SD serum uric acid for all individuals was 5.14 +/- 1.5 mg/dl. Serum uric acid was found to be significantly heritable (0.46 +/- 0.03 in all centers, and 0.39 +/- 0.07, 0.51 +/- 0.05, 0.44 +/- 0.06 in Arizona, Dakotas and Oklahoma, respectively). Multipoint linkage analysis showed significant evidence of linkage for serum uric acid on chromosome 11 in the Dakotas center [logarithm of odds score (LOD) = 3.02] and in the combined sample (LOD = 3.56) and on chromosome 1 (LOD = 3.51) in the combined sample. A strong positional candidate gene in the chromosome 11 region is solute carrier family22, member 12 (SLC22A12) that encodes a major uric acid transporter URAT1. These results show a significant genetic influence and a possible role for one or more genes on chromosomes 1 and 11 on the variation in serum uric acid in American Indian populations.
Authors:
V Saroja Voruganti; Harald H H Göring; Amy Mottl; Nora Franceschini; Karin Haack; Sandra Laston; Laura Almasy; Richard R Fabsitz; Elisa T Lee; Lyle G Best; Richard B Devereux; Barbara V Howard; Jean W MacCluer; Anthony G Comuzzie; Jason G Umans; Shelley A Cole
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-07-10
Journal Detail:
Title:  Human genetics     Volume:  126     ISSN:  1432-1203     ISO Abbreviation:  Hum. Genet.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-02     Completed Date:  2010-01-06     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  667-76     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Arizona / epidemiology
Carrier State
Chromosome Mapping
Chromosomes, Human, Pair 11*
Family
Female
Genetic Variation*
Genotype
Humans
Hyperuricemia / epidemiology,  genetics*
Indians, North American / genetics*,  statistics & numerical data*
Lod Score
Male
North Dakota / epidemiology
Oklahoma / epidemiology
Pedigree
Phenotype
South Dakota / epidemiology
Uric Acid / blood*
Grant Support
ID/Acronym/Agency:
C06 RR013556/RR/NCRR NIH HHS; C06 RR013556-01/RR/NCRR NIH HHS; C06 RR014578/RR/NCRR NIH HHS; C06 RR014578/RR/NCRR NIH HHS; C06 RR014578-01/RR/NCRR NIH HHS; C06 RR015456/RR/NCRR NIH HHS; C06 RR015456/RR/NCRR NIH HHS; C06 RR015456-01A1/RR/NCRR NIH HHS; C06 RR017515/RR/NCRR NIH HHS; C06 RR017515-01A1/RR/NCRR NIH HHS; MH59490/MH/NIMH NIH HHS; R37 MH059490/MH/NIMH NIH HHS; R37 MH059490-11/MH/NIMH NIH HHS; U01 HL041642/HL/NHLBI NIH HHS; U01 HL041642-19/HL/NHLBI NIH HHS; U01 HL041652/HL/NHLBI NIH HHS; U01 HL041652-20/HL/NHLBI NIH HHS; U01 HL041654/HL/NHLBI NIH HHS; U01 HL041654-20/HL/NHLBI NIH HHS; U01 HL065520/HL/NHLBI NIH HHS; U01 HL065520-09/HL/NHLBI NIH HHS; U01 HL065521/HL/NHLBI NIH HHS; U01 HL065521-08/HL/NHLBI NIH HHS; U01-HL41642/HL/NHLBI NIH HHS; U01-HL41652/HL/NHLBI NIH HHS; U01-HL41654/HL/NHLBI NIH HHS; U01-HL65520/HL/NHLBI NIH HHS; U01-HL65521/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
268B43MJ25/Uric Acid
Comments/Corrections

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