Document Detail


Genetic identification of an On-Off direction-selective retinal ganglion cell subtype reveals a layer-specific subcortical map of posterior motion.
MedLine Citation:
PMID:  19447089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Motion detection is an essential component of visual processing. On-Off direction-selective retinal ganglion cells (On-Off DSGCs) detect objects moving along specific axes of the visual field due to their precise retinal circuitry. The brain circuitry of On-Off DSGCs, however, is largely unknown. We report a mouse with GFP expressed selectively by the On-Off DSGCs that detect posterior motion (On-Off pDSGCs), allowing two-photon targeted recordings of their light responses and delineation of their complete map of central connections. On-Off pDSGCs project exclusively to the dorsal lateral geniculate nucleus and superior colliculus and in both targets form synaptic lamina that are separate from a lamina corresponding to non-DSGCs. Thus, individual On-Off DSGC subtypes are molecularly distinct and establish circuits that map specific qualities of directional motion to dedicated subcortical areas. This suggests that each RGC subtype represents a unique parallel pathway whose synaptic specificity in the retina is recapitulated in central targets.
Authors:
Andrew D Huberman; Wei Wei; Justin Elstrott; Ben K Stafford; Marla B Feller; Ben A Barres
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Neuron     Volume:  62     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-18     Completed Date:  2009-06-23     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  327-34     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Mapping*
Geniculate Bodies / cytology,  physiology*
Green Fluorescent Proteins / genetics,  metabolism
Luminescent Agents / metabolism
Mice
Mice, Inbred C57BL
Mice, Transgenic
Motion Perception / physiology*
Retinal Ganglion Cells / classification,  metabolism,  physiology*
Superior Colliculi / cytology,  physiology*
Synapses / metabolism
Visual Pathways / cytology,  physiology*
Grant Support
ID/Acronym/Agency:
R01 EY011310/EY/NEI NIH HHS; R01 EY011310-13/EY/NEI NIH HHS; R01 EY011310-13/EY/NEI NIH HHS; R01 EY013528/EY/NEI NIH HHS; R01 EY013528-09/EY/NEI NIH HHS; R01 EY019498/EY/NEI NIH HHS; R01 EY019498-01/EY/NEI NIH HHS; R01 EY13528/EY/NEI NIH HHS; R21 EY018320/EY/NEI NIH HHS; R21 EY018320/EY/NEI NIH HHS; R21 EY018320-02/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Luminescent Agents; 147336-22-9/Green Fluorescent Proteins
Comments/Corrections

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