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Genetic factors related to gastric-cancer susceptibility identified by GWAS.
MedLine Citation:
PMID:  23057512     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Gastric cancer (GC) is one of the major malignant diseases worldwide, especially in Asia, where Japan and Korea have the highest incidence in the world. GC is classified into intestinal and diffuse types. While the former is almost absolutely caused by Helicobacter pylori infection as initial insult, the latter seems to include the cases in which the role of the infection is limited, if any, and a contribution of genetic factors is anticipated. Previously, we performed a genome-wide association study (GWAS) on the diffuse-type GC by utilizing single nucleotide polymorphisms (SNPs) catalogued for Japanese (JSNP), and identified prostate stem cell antigen gene (PSCA) encoding a glycosylphosphatidylinositol-anchored cell surface antigen as a GC susceptibility gene. From the second candidate locus identified by the GWAS, 1q22, we found the Mucin 1 gene (MUC1) encoding a cell membrane-bound mucin protein as another gene related to diffuse-type GC. A two-allele analysis based on risk genotypes of the 2 genes revealed approximately 95 % of Japanese have at least one of the 2 risk genotypes, and about 56% of the population have both risk genotypes. The 2-SNP genotype may offer ample room to further stratify a high GC risk subpopulation in Japan and Asia by adding another genetic and/or non-genetic factor. Recently, a GWAS on the Chinese population disclosed additional 3 GC-susceptibility loci: 3q13.31, 5p13.1 and 10q23.
Authors:
Norihisa Saeki; Hiroe Ono; Hiromi Sakamoto; Teruhiko Yoshida
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-12
Journal Detail:
Title:  Cancer science     Volume:  -     ISSN:  1349-7006     ISO Abbreviation:  Cancer Sci.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101168776     Medline TA:  Cancer Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Japanese Cancer Association.
Affiliation:
Division of Genetics, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo, 104-0045, Japan.
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