Document Detail

Genetic factors in the electrocardiogram and heart rate of twins reared apart and together.
MedLine Citation:
PMID:  2919564     Owner:  NLM     Status:  MEDLINE    
Important physiologic mechanisms have been thought not to exhibit large amounts of variability, due in part to the assumption that critical biologic functions will have evolved to an evolutionary optimum. The attainment of this optimum would necessarily eliminate individual differences in these variables. Using a sample of monozygotic and dizygotic twins reared apart since birth or early infancy, 12-lead electrocardiographic recordings and vectorcardiograms were obtained. Values of these variables for monozygotic and dizygotic twins reared together were obtained from other studies. Maximum likelihood tests of genetic and environmental components of variation for PR interval, QRS duration, QT interval and ventricular rate indicated a significant contribution of genetic effects (most heritabilities ranged from 30 to 60%), with a negligible contribution from common familial environmental effects.
B Hanson; N Tuna; T Bouchard; L Heston; E Eckert; D Lykken; N Segal; S Rich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  63     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-03-30     Completed Date:  1989-03-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  606-9     Citation Subset:  AIM; IM    
Department of Medicine, University of Minnesota, Minneapolis.
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MeSH Terms
Genetic Variation*
Heart Rate*
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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