Document Detail


Genetic factors in athetoid cerebral palsy.
MedLine Citation:
PMID:  11732763     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Within the cerebral palsy syndromes, athetosis is most commonly causally associated with serious perinatal complications. Genetic factors are thought to play a lesser role, although the risk of recurrence in siblings has been suggested to be as high as 10%. We have conducted a clinical study of 22 subjects with a diagnosis of athetoid cerebral palsy and a review of the literature aiming to identify instances of familial recurrence of athetoid cerebral palsy. The birth history, family history, and previous investigations of subjects with athetoid cerebral palsy were studied and subjects were clinically examined for evidence of an underlying genetic etiology. Factors suggesting a genetic cause were specifically sought, such as advanced paternal age, progression of symptoms, and associated congenital abnormalities. No subjects in the study group had similarly affected relatives, and additional features suggesting a genetic cause were not observed. A literature search identified 16 instances of familial recurrence of athetoid cerebral palsy. Familial cases were typically associated with significant spasticity, microcephaly, intellectual disability, seizures, and a lack of history of birth asphyxia, and most could be explained by either autosomal-recessive or X-linked-recessive inheritance. The genetic contribution to athetoid cerebral palsy is small, with an overall risk of recurrence in siblings of about 1%. This risk is lower than previously suggested in the literature.
Authors:
D J Amor; J E Craig; M B Delatycki; D Reddihough
Related Documents :
10723683 - Survival, cranial ultrasound and cerebral palsy in very low birthweight infants: 1980s ...
2332013 - Continuous cerebral electrical impedance monitoring in sick preterm infants.
23456903 - Prophylactic indomethacin worsens short-term respiratory outcomes in extremely low-birt...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of child neurology     Volume:  16     ISSN:  0883-0738     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-12-04     Completed Date:  2002-03-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  793-7     Citation Subset:  IM    
Affiliation:
Genetic Health Services Victoria, Royal Children's Hospital, Parkville, Australia. amord@cryptic.rch.unimelb.edu.au
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cerebral Palsy / genetics*
Child
Child, Preschool
Female
Humans
Male

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Long-term developmental outcome of asphyxiated term neonates.
Next Document:  Patterns of cerebral glucose metabolism in early and late stages of Rasmussen's syndrome.