Document Detail

Genetic factors associated with volume-sensitive hypertension.
MedLine Citation:
PMID:  15134799     Owner:  NLM     Status:  MEDLINE    
Defining the genetic basis of essential hypertension is most informative when the blood pressure regulation is correlated with physiologic mechanisms, e.g., responses of the renin-angiotensin aldosterone system (RAAS) in hypertensive subjects. The aldosterone response to angiotensin II (Ang II) on a low salt diet is influenced by gender, plasma renin activity, and most significantly, familial resemblance, but only in males and in post-menopausal females. There is familial aggregation of low-renin hypertension, no association with candidate genes of the RAAS, but, a highly significant association with polymorphisms in the alpha-adducin gene. Finally, angiotensinogen (AGT) genotype effects renal and adrenal responses to Ang II in patients with hypertension. These results strongly suggest that in contrast to population-based studies that use hypertension as the phenotype, classifying patients by the variability in physiologic, mechanistic traits enhances the probability of identifying the genetic factors influencing a rise in blood pressure.
Gordon H Williams
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  217     ISSN:  0303-7207     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-05-11     Completed Date:  2005-02-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  41-4     Citation Subset:  IM    
Endocrinology, Diabetes and Hypertension Division, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, RFB-2, Boston, MA 02115, USA.
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MeSH Terms
Age Factors
Aldosterone / blood
Angiotensin II / administration & dosage
Angiotensinogen / genetics
Blood Volume
Calmodulin-Binding Proteins / genetics*
Diet, Sodium-Restricted
Genetic Predisposition to Disease*
Hypertension / blood,  drug therapy,  genetics*,  physiopathology
Predictive Value of Tests
Renin / blood
Renin-Angiotensin System / physiology
Sex Factors
Vasoconstrictor Agents / administration & dosage
Reg. No./Substance:
0/Calmodulin-Binding Proteins; 0/Vasoconstrictor Agents; 0/adducin; 11002-13-4/Angiotensinogen; 11128-99-7/Angiotensin II; 52-39-1/Aldosterone; EC

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