| Genetic evaluation and management of fetal chylothorax: review and insights from a case of Noonan syndrome. | |
| | |
MedLine Citation:
|
PMID: 19927903 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Fetal chylothorax is one of a very few syndromes that can be treated in utero with thoracoamniotic shunting or pleurodesis by OK-432 as two major therapeutic modalities. We report on a fetus with Noonan syndrome and a missense mutation c.182A > C (p.Asp61Ala) of PTPN11 who responded poorly to antenatal pleurodesis by OK-432. Based on our previous publication and this case study, we propose that fetal chylothorax of a distinct genetic origin may respond poorly to OK-432 pleurodesis. |
| | |
Authors:
|
C H Chen; T H Chen; S J Kuo; C P Chen; D J Lee; Y Y Ke; K T Yeh; G C Ma; C S Liu; J C Shih; M Chen |
Related Documents
:
|
16542393 - A novel homozygous mmp2 mutation in a family with winchester syndrome. 10677303 - Familial syndromic esophageal atresia maps to 2p23-p24. 18411133 - Cushing's syndrome: difficulties in diagnosis. |
Publication Detail:
|
Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Lymphology Volume: 42 ISSN: 0024-7766 ISO Abbreviation: Lymphology Publication Date: 2009 Sep |
Date Detail:
|
Created Date: 2009-11-20 Completed Date: 2009-12-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0155112 Medline TA: Lymphology Country: United States |
Other Details:
|
Languages: eng Pagination: 134-8 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Chylothorax / congenital*, genetics*, ultrasonography Female Fetal Death Genotype Humans Mutation, Missense Noonan Syndrome / genetics*, ultrasonography Pleurodesis Pregnancy Treatment Failure Ultrasonography, Prenatal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Post-lymphangiographic computed tomography in chylothorax after esophagogastrectomy: a case report.
Next Document: Airplane travel and lymphedema: a case study.