Document Detail

Genetic evaluation and management of fetal chylothorax: review and insights from a case of Noonan syndrome.
MedLine Citation:
PMID:  19927903     Owner:  NLM     Status:  MEDLINE    
Fetal chylothorax is one of a very few syndromes that can be treated in utero with thoracoamniotic shunting or pleurodesis by OK-432 as two major therapeutic modalities. We report on a fetus with Noonan syndrome and a missense mutation c.182A > C (p.Asp61Ala) of PTPN11 who responded poorly to antenatal pleurodesis by OK-432. Based on our previous publication and this case study, we propose that fetal chylothorax of a distinct genetic origin may respond poorly to OK-432 pleurodesis.
C H Chen; T H Chen; S J Kuo; C P Chen; D J Lee; Y Y Ke; K T Yeh; G C Ma; C S Liu; J C Shih; M Chen
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Lymphology     Volume:  42     ISSN:  0024-7766     ISO Abbreviation:  Lymphology     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-11-20     Completed Date:  2009-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155112     Medline TA:  Lymphology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  134-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan.
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MeSH Terms
Chylothorax / congenital*,  genetics*,  ultrasonography
Fetal Death
Mutation, Missense
Noonan Syndrome / genetics*,  ultrasonography
Treatment Failure
Ultrasonography, Prenatal

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