| Genetic and epigenetic signatures of breast cancer subtypes. | |
| | |
MedLine Citation:
|
PMID: 22201926 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Breast cancer is a heterogeneous disease at both the histological and molecular levels. The current model of breast tumorigenesis suggests that the normal mammary stem cell and the various progenitors that arise thereof can be transformed and generate lineage-restricted tumor phenotypes. This model is supported by observations that the different subtypes of breast cancer share transcriptional signatures intrinsic to normal components of the mammary epithelium. Studies have since elaborated these molecular signatures to include recurrent genetic abnormalities, patterns of DNA methylation and dysregulation of microRNAs. Here we aim to review the current state of knowledge concerning the cellular etiology of breast cancer subtypes and the genetic, transcriptional and epigenetic aberrations associated with each subtype. |
| | |
Authors:
|
Shane R Stecklein; Roy A Jensen; Arindam Pal |
Related Documents
:
|
9240296 - An experimental model for the prevention of postanastomotic tracheal stenosis. 21595656 - Basal cell carcinoma: evidence-based medicine and review of treatment modalities. 2273076 - Prophylactic effects of psychoanalysis on cancer-prone and coronary heart disease-prone... 21624656 - [interferon alpha 2β, partial keratectomy and amniotic membrane transplant for the tre... 16531766 - Mucinous colorectal cancers with chromosomal instability: a biologically distinct and a... 3361866 - Mammobarography: a possible method of mass breast screening. |
Publication Detail:
|
Type: Journal Article Date: 2012-01-01 |
Journal Detail:
|
Title: Frontiers in bioscience (Elite edition) Volume: 4 ISSN: 1945-0508 ISO Abbreviation: Front Biosci (Elite Ed) Publication Date: 2012 |
Date Detail:
|
Created Date: 2011-12-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101485240 Medline TA: Front Biosci (Elite Ed) Country: United States |
Other Details:
|
Languages: eng Pagination: 934-49 Citation Subset: IM |
Affiliation:
|
Department of Pathology and Laboratory Medicine and The University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, KS. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nonsyndromic X-linked hearing loss.
Next Document: Increased levels of hemoglobin and alpha1-microglobulin in Huntington's disease.