Document Detail

Genetic-epigenetic intersection in trophoblast differentiation: implications for extraembryonic tissue function.
MedLine Citation:
PMID:  20083894     Owner:  NLM     Status:  MEDLINE    
Recent years have seen considerable advances in our understanding of early mammalian development leading up to the establishment of the first cell lineages, with important implications for the behavior of stem cells derived from the early embryo. Dramatic new insights have also propelled the field of epigenetics with the identification of 5-hydroxymethylcytosine as an additional base modification and the pervasiveness of asymmetrical non-CG DNA methylation specifically in ES cells. Prompted by our findings on the role of DNA methylation in cell lineage commitment, this review highlights recent insights into the genetic-epigenetic intersection in the establishment of the placental trophoblast lineage that is essential for embryo implantation, nutrition and survival. The unique trophoblast epigenotype is instrumental for normal trophoblast differentiation and placental function, and consequently trophoblast is particularly susceptible to regrogramming failures.
Myriam Hemberger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-01-09
Journal Detail:
Title:  Epigenetics : official journal of the DNA Methylation Society     Volume:  5     ISSN:  1559-2308     ISO Abbreviation:  Epigenetics     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-26     Completed Date:  2010-05-25     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  101265293     Medline TA:  Epigenetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  24-9     Citation Subset:  IM    
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MeSH Terms
Cell Differentiation
Cytosine / analogs & derivatives,  metabolism
DNA Methylation
Embryonic Stem Cells / cytology
Epigenesis, Genetic*
Gene Expression Regulation*
Models, Biological
Models, Genetic*
Placenta / metabolism
Plants / genetics
Stem Cells / cytology
Trophoblasts / metabolism*
Grant Support
G0800784//Medical Research Council; //Biotechnology and Biological Sciences Research Council; //Medical Research Council
Reg. No./Substance:
1123-95-1/5-hydroxymethylcytosine; 8J337D1HZY/Cytosine

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