Document Detail


Genetic and epigenetic influences associated with intrauterine growth restriction due to in utero tobacco exposure.
MedLine Citation:
PMID:  21150839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
While many fetuses are exposed to tobacco in utero, not all experience adverse outcomes as a result of this exposure. Mechanisms leading to the attenuation of fetal birth weight and adverse pregnancy outcomes are complex. Therefore many studies have begun to focus, not only on the contribution of maternal and fetal genes to phenotypic outcome, but also on epigenetic changes associated with exposure to maternal tobacco smoke. In this review, we detail the epidemiologic evidence associating an adverse pregnancy outcome to maternal tobacco use. We provide a brief summary of studies demonstrating an association between maternal and fetal gene polymorphisms with low birth weight in response to maternal tobacco exposure. We also review the literature showing epigenetic changes in the offspring associated with in utero tobacco exposure. The complex interplay of genomic and epigenomic factors may contribute to specific phenotypic outcomes and can help begin to elucidate the differential susceptibilities to tobacco smoke in utero.
Authors:
Melissa Suter; Adi Abramovici; Kjersti Aagaard-Tillery
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Pediatric endocrinology reviews : PER     Volume:  8     ISSN:  1565-4753     ISO Abbreviation:  Pediatr Endocrinol Rev     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101202124     Medline TA:  Pediatr Endocrinol Rev     Country:  Israel    
Other Details:
Languages:  eng     Pagination:  94-102     Citation Subset:  IM    
Affiliation:
Baylor College of Medicine, Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, One Baylor Plaza, Houston, TX 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Epigenesis, Genetic / genetics*
Female
Fetal Growth Retardation / etiology*,  genetics*
Humans
Infant, Newborn
Pre-Eclampsia / genetics
Pregnancy
Prenatal Exposure Delayed Effects / genetics*
Smoking / adverse effects*
Grant Support
ID/Acronym/Agency:
DP20D001500/DP/NCCDPHP CDC HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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