Document Detail


Genetic epidemiology of HbS in Oman: multicentric origin for the betaS gene.
MedLine Citation:
PMID:  10815786     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
On the basis of a sample of 117 chromosomes, we have demonstrated the multicentric origin of the sickle mutation in Northern Oman. Three major haplotypes coexist: 52.1% Benin (typical and atypicals), 26.7% Arab-India, and 21.4% Bantu. These haplotypes are not autochthonous to Oman but originated elsewhere and arrived in Oman by gene flow. The distribution of haplotypes is in excellent agreement with the historical record, which establishes clear ancient contacts between Oman and sub-Sahara west Africa and explains the presence of the Benin haplotype; contacts with Iraq, Iran, present-day Pakistan, and India explain the presence of the Arab-India haplotype. More recent contacts with East Africa (Zanzibar/Mombasa) explain the presence of the Bantu haplotype. The pattern of the Arab-India haplotype in the populations of the Arabian peninsula reinforces the hypothesis that this particular mutation originated in the Harappa culture or in a nearby population and in addition reveals that the Sassanian Empire might have been the vehicle by which this Indo-European sickle mutation migrated (gene flow) to the present-day Arabian peninsula, including Oman.
Authors:
S Daar; H M Hussain; D Gravell; R L Nagel; R Krishnamoorthy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hematology     Volume:  64     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-05-31     Completed Date:  2000-05-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  39-46     Citation Subset:  IM    
Affiliation:
Department of Hematology, College of Medicine, Sultan Qaboos University, Muscat, Sultanate of Oman.
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MeSH Terms
Descriptor/Qualifier:
Hemoglobin, Sickle / genetics*
Humans
Mutation*
Oman / epidemiology
beta-Thalassemia / epidemiology*,  genetics*
Chemical
Reg. No./Substance:
0/Hemoglobin, Sickle

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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