| Genetic and environmental influences on human cord blood leptin concentration. | |
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MedLine Citation:
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PMID: 10224179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine in a population sample of cord blood the time structure (chronome) of leptin, an adipocyte-derived hormone, and to assess any effect of a familial history of noninsulin-dependent diabetes mellitus and obesity, separately, on both the maternal and the paternal side. SUBJECTS AND METHODS: Leptin concentration was determined in cord blood from 93 infants. Effects of gender, gestational age, birth weight, maternal weight, familial antecedents of obesity and noninsulin-dependent diabetes mellitus, and circadian and about-yearly stage were assessed by linear regression and ANOVA. RESULTS: Cord blood leptin concentration is elevated in the presence of a family history of obesity on the paternal side, but not on the maternal side. Leptin concentrations are higher in spring and summer than in fall and are higher in infants born before noon. In keeping with earlier work, leptin concentration in cord blood correlates positively with birth weight and height and is higher in infants who are appropriate for or large for gestational age than in infants who are small for gestational age or born prematurely. DISCUSSION: Changes along the scales of the day and the seasons point to synchronizing environmental as well as genetic influence. An association of cord blood leptin concentration with obesity on the paternal side may help clarify the role of leptin in parental contributions to human obesity and may prompt focus on cholesterol metabolism. |
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Authors:
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B Tarquini; R Tarquini; F Perfetto; G Cornélissen; F Halberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pediatrics Volume: 103 ISSN: 0031-4005 ISO Abbreviation: Pediatrics Publication Date: 1999 May |
Date Detail:
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Created Date: 1999-05-28 Completed Date: 1999-05-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 998-1006 Citation Subset: AIM; IM |
Affiliation:
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Cattedra di Medicina Interna, Istituto di Clinica Medica Generale e Terapia Medica IV, Florence, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Circadian Rhythm Diabetes Mellitus / genetics Diabetes Mellitus, Type 2 / blood, genetics* Female Fetal Blood / chemistry* Humans Infant, Newborn Infant, Small for Gestational Age Leptin Male Obesity / genetics* Proteins / metabolism* Random Allocation Seasons Sex Factors Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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GM-13981/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 0/Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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