Document Detail


Genetic and environmental influences on human birth weight.
MedLine Citation:
PMID:  3591799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Path-analytic techniques were used to demonstrate a significant influence of both fetal genes and maternal environment on birth weight in a sample of infants born to primarily white, middle-class, nonsmoking mothers. If the mother smoked before conception, however, the expression of the fetal birth-weight genes in males was significantly reduced. Multiparity was associated with an increase in genetic variance. This is the first report that genetic influences on birth weight are dependent on the environmental conditions imposed on the fetus by the mother.
Authors:
R E Little; C F Sing
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of human genetics     Volume:  40     ISSN:  0002-9297     ISO Abbreviation:  Am. J. Hum. Genet.     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-07-20     Completed Date:  1987-07-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370475     Medline TA:  Am J Hum Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  512-26     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking
Birth Weight*
Environment
Female
Humans
Infant, Newborn
Male
Models, Genetic*
Parity
Pregnancy
Smoking
Grant Support
ID/Acronym/Agency:
HD06608/HD/NICHD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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