Document Detail

Genetic and environmental effects on carotid flow velocities: An international twin study.
MedLine Citation:
PMID:  24267227     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: Altered carotid blood flow velocities (CFV) have a complex background but the underlying genetic contribution is still unclear. We sought to evaluate the influence of genetics, shared and unshared environmental components on individual differences of CFV.
METHODS: 193 healthy twin pairs, 126 monozygotic (MZ) and 67 dizygotic (DZ) (mean age 53 ± 14 years) recruited in Italy, in the United States and in Hungary underwent bilateral color-coded Doppler flow assessment of the common carotid artery (CCA) and of the internal carotid artery (ICA) in order to assess the peak systolic (PSV) and end diastolic (EDV) velocities. Means of bilateral CFV values were used in the analysis.
RESULTS: Age- and country-adjusted intra-class correlations were higher in monozygotic than in dizygotic pairs for mean PSV of the ICA indicating a heritability of 63%. Unique environmental factors contributed to 37% of ICA PSV. With regards to the mean PSV and EDV of the CCA, and EDV of the ICA, heritability analysis indicated no discernible role for genetic components, while the contributions of shared and unshared environmental factors ranged between 56% and 63%, and between 37% and 44% adjusted for age and country, respectively. Mean ICA/CCA ratio was driven by unique environmental factors (82%) with modest heritability (18%).
CONCLUSIONS: Our study showed that the heritability of ICA PSV and ICA/CCA ratio is moderate, while the findings do not support heritability of other investigated CFV values. Environmental effects account for a moderate to major portion of the variance. These findings support the value of early ultrasound screening as well as the prevention of modifiable environmental factors in case of altered carotid flow velocities.
Pierleone Lucatelli; Adam Domonkos Tarnoki; David Laszlo Tarnoki; Maria Fabrizia Giannoni; Marianna Gazzetti; Emanuele Boatta; Chiara Zini; Rodolfo Cotichini; Claudio Baracchini; Giorgio Meneghetti; Lorenza Nisticó; Corrado Fagnani; Kinga Karlinger; Tamas Horvath; Andrea Agnes Molnar; Zsolt Garami; Emanuela Medda; Maria Antonietta Stazi; Viktor Berczi; Fabrizio Fanelli
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Publication Detail:
Type:  Journal Article     Date:  2013-09-08
Journal Detail:
Title:  Atherosclerosis     Volume:  231     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-11-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  205-10     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
Vascular and Interventional Radiology Unit, Department of Radiology, Oncology and Anatomic Pathology, Policlinico Umberto I, "Sapienza" University of Rome, Viale Regina Elena 324, Rome 00161, Italy. Electronic address:
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