| Genetic and environmental determinants of cholesterol and HDL-cholesterol concentrations in blood. | |
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MedLine Citation:
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PMID: 6682407 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum cholesterol and HDL-cholesterol have been studied in 274 Swedish nuclear families. The families were ascertained through the Swedish twin registry and consisted of married mono- and dizygous twins, their spouses and with at least one adult child. Total cholesterol was determined using an enzymatic colorimetric method and HDL-cholesterol by the heparin-manganese chloride precipitation method. The genetic analysis was performed using a path analytic model to resolve genetic and cultural heritability, marital correlations and maternal effects. Genetic heritability was 0.50 and 0.37 for total cholesterol and HDL-cholesterol, respectively. Cultural heritability was small, 0.04, for cholesterol but substantial 0.22, for HDL-cholesterol. A maternal effect was evident for cultural inheritance for HDL-cholesterol but not for cholesterol. |
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Authors:
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G Dahlén; C Ericson; U de Faire; L Iselius; T Lundman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: International journal of epidemiology Volume: 12 ISSN: 0300-5771 ISO Abbreviation: Int J Epidemiol Publication Date: 1983 Mar |
Date Detail:
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Created Date: 1983-06-10 Completed Date: 1983-06-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7802871 Medline TA: Int J Epidemiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 32-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cholesterol / blood, genetics* Cholesterol, HDL Culture Environment Family Female Humans Lipoproteins, HDL / blood, genetics* Male Pregnancy Sex Factors Sweden Twins, Dizygotic Twins, Monozygotic |
| Grant Support | |
ID/Acronym/Agency:
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GM 23498/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Lipoproteins, HDL; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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