Document Detail


Genetic effects of a titanium surface on osteoblasts: a meta-analysis.
MedLine Citation:
PMID:  18195514     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Titanium is used worldwide to make osseointegrable devices. The favorable characteristics that make this material desirable for implantation are i) its mechanical properties and ii) its biocompatibility. The latter has been demonstrated by in vivo studies with animal models and clinical trials over a forty-year period. However, the exact genetic effect of the titanium layer on cells is still not well characterized. To detect the genetic effect of titanium surfacing on osteoblasts without porosity as a confounding variable, a meta-analysis of genetic expression profiling obtained from several titanium surfaces was performed. One hundred seventy-three genes were selected, 84 up-regulated and 95 down-regulated. Among them, the most notable were genes that participate in osteoblast differentiation and bone regeneration, such as TIMP1, PTN, and RUNX1. Titanium surfacing has i) a direct genetic effect on osteoblasts, ii) induces several bone-related genes, and iii) is relevant to the osseointegration process. These properties should be taken into consideration in separating the effect of porosity (i.e. the micro-dimension) from implant coating (i.e. the nano-dimension).
Authors:
Diego Arcelli; Annalisa Palmieri; Furio Pezzetti; Giorgio Brunelli; Ilaria Zollino; Francesco Carinci
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of oral science     Volume:  49     ISSN:  1343-4934     ISO Abbreviation:  J Oral Sci     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-01-15     Completed Date:  2008-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9808942     Medline TA:  J Oral Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  299-309     Citation Subset:  D; IM    
Affiliation:
Dermopatic Institute of the Immacolata, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Cell Adhesion / genetics
Cell Differentiation / genetics
Cells, Cultured
Down-Regulation
Gene Expression Profiling*
Humans
Morphogenesis / genetics
Oligonucleotide Array Sequence Analysis
Osseointegration / genetics
Osteoblasts / drug effects*
Osteogenesis / genetics
Surface Properties
Titanium / pharmacology*
Up-Regulation
Chemical
Reg. No./Substance:
7440-32-6/Titanium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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