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Genetic effects of adiponectin on blood lipids and blood pressure.
MedLine Citation:
PMID:  21054480     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: Results from the published studies on the association of adiponectin gene (ADIPOQ) polymorphisms with blood lipids and blood pressure are conflicting. We investigated the association of three ADIPOQ polymorphisms, +45 T > G (rs2241766), +276 G > T (rs1501299) and -11377 C > G (rs266729), with these traits in this meta-analysis.
RESEARCH DESIGN AND METHODS: We included 35 studies in this meta-analysis. Dominant models were used for this meta-analysis.
RESULTS: We did not detect a significant association of the -11377 C > G polymorphism with blood lipids or blood pressure (P > 0·05). The association of the +45 T > G polymorphism with blood lipids and blood pressure was, similarly, not significant (P > 0·05). The meta-analysis suggested a significant overall association of the +276 G > T polymorphism with lower levels of total cholesterol: weighted mean difference (WMD) = -0·10, 95% confidence interval (CI, -0·17, -0·03), P = 0·005, P(heterogeneity)  = 0·04. This association was marginally significant in East Asians and East Asians with type 2 diabetes: WMD = -0·10, 95% CI (-0·20, 0·00), P = 0·05, P(heterogeneity)  = 0·002, and WMD = -0·09, 95% CI (-0·18, -0·00), P = 0·05, P(heterogeneity)  = 0·80, respectively. After exclusion of a study that was the source of heterogeneity, the association was significant in overall populations and marginally significant in East Asians: WMD= -0·06, 95% CI (-0·11, -0·01), P = 0·01, P(heterogeneity)  = 0·98, and WMD = -0·06, 95% CI (-0·12, 0·00), P = 0·07, P(heterogeneity)  = 0·83, respectively. However, none of these associations were significant after Bonferroni correction (significant threshold: P < 0·003).
CONCLUSIONS: Our meta-analysis does not suggest any association of the three ADIPOQ polymorphisms with blood lipids and blood pressure.
Authors:
Tongfeng Zhao; Jiangpei Zhao
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical endocrinology     Volume:  74     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  214-22     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Affiliation:
Department of Geriatrics, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. zhaotongfeng@yahoo.com.cn
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