Document Detail

Genetic effects on PCP-induced stimulation in recombinant inbred strains of mice.
MedLine Citation:
PMID:  6463086     Owner:  NLM     Status:  MEDLINE    
The stimulation of motor activity by phencyclidine was found to differ significantly in BALB/c and C57Bl/6By inbred strains of mice. Phencyclidine-induced stimulation was compared for these strains, their reciprocal F1 hybrids, and their recombinant inbred offspring. There were significant differences in responsivity among the strains, suggesting a genetic influence on the PCP response; however, the strains did not segregate into two distinct groupings, suggesting that this genetic influence was not carried by a single gene. In addition, there was no relationship between the responsivity of these strains of mice to PCP and their previously-reported responses to amphetamine or scopolamine, which suggests that PCP-induced stimulation is not a simple cholinergic or amphetamine-like response.
W J Freed; S Crump; D V Jeste
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  21     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-09-19     Completed Date:  1984-09-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  159-62     Citation Subset:  IM    
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MeSH Terms
Amphetamine / pharmacology
Hybridization, Genetic
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred Strains
Motor Activity / drug effects*
Phencyclidine / pharmacology*
Phenethylamines / pharmacology
Scopolamine / pharmacology
Species Specificity
Reg. No./Substance:
0/Phenethylamines; 300-62-9/Amphetamine; 51-34-3/Scopolamine; 77-10-1/Phencyclidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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