Document Detail


Genetic effects on PCP-induced stimulation in recombinant inbred strains of mice.
MedLine Citation:
PMID:  6463086     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The stimulation of motor activity by phencyclidine was found to differ significantly in BALB/c and C57Bl/6By inbred strains of mice. Phencyclidine-induced stimulation was compared for these strains, their reciprocal F1 hybrids, and their recombinant inbred offspring. There were significant differences in responsivity among the strains, suggesting a genetic influence on the PCP response; however, the strains did not segregate into two distinct groupings, suggesting that this genetic influence was not carried by a single gene. In addition, there was no relationship between the responsivity of these strains of mice to PCP and their previously-reported responses to amphetamine or scopolamine, which suggests that PCP-induced stimulation is not a simple cholinergic or amphetamine-like response.
Authors:
W J Freed; S Crump; D V Jeste
Related Documents :
21336686 - Antifungal activity of essential oils and their synergy with fluconazole against drug-r...
21329346 - Characterization of microbial fuel cells at microbially and electrochemically meaningfu...
21490186 - Development of echinocandin resistance in clavispora lusitaniae during caspofungin trea...
8111126 - Association of xmv-10 and the non-agouti (a) mutation explained by close linkage instea...
8335496 - The accessibility of cross-reactive anti-lipopolysaccharide-core monoclonal antibodies ...
12054256 - Oleiphilaceae fam. nov., to include oleiphilus messinensis gen. nov., sp. nov., a novel...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  21     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-09-19     Completed Date:  1984-09-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  159-62     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amphetamine / pharmacology
Animals
Hybridization, Genetic
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred Strains
Motor Activity / drug effects*
Phencyclidine / pharmacology*
Phenethylamines / pharmacology
Scopolamine / pharmacology
Species Specificity
Chemical
Reg. No./Substance:
0/Phenethylamines; 300-62-9/Amphetamine; 51-34-3/Scopolamine; 77-10-1/Phencyclidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The up-and-down method for the determination of nociceptive thresholds in rats.
Next Document:  Memory retention test performance in mice: improvement by chronic oral cholinergic drug treatment.